Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Nourianz Generic Name & Formulations
Legal Class
Rx
General Description
Istradefylline 20mg, 40mg; tabs.
Pharmacological Class
Adenosine receptor antagonist.
How Supplied
Tabs—90
Manufacturer
Generic Availability
NO
Nourianz Indications
Indications
As adjunct to levodopa/carbidopa in adults with Parkinson's disease experiencing "off" episodes.
Nourianz Dosage and Administration
Adult
20mg once daily. May increase to max 40mg once daily, if needed and tolerated. Concomitant strong CYP3A4 inhibitors: max 20mg once daily. Moderate hepatic impairment: max 20mg once daily; monitor closely. Smokers (≥20 cigarettes/day): 40mg once daily.
Children
Not established.
Nourianz Contraindications
Not Applicable
Nourianz Boxed Warnings
Not Applicable
Nourianz Warnings/Precautions
Warnings/Precautions
Pre-existing dyskinesia. Avoid in major psychotic disorder. Consider dose reduction or discontinuation if hallucinations, psychotic behaviors, or urges/compulsive behaviors develop. Severe hepatic impairment: avoid. ESRD and/or requiring hemodialysis. Advise females of reproductive potential to use effective contraception during treatment. Pregnancy: not recommended. Nursing mothers.
Nourianz Pharmacokinetics
See Literature
Nourianz Interactions
Interactions
Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin); see Adults. Antagonized by strong CYP3A4 inducers (eg, carbamazepine, rifampin, phenytoin, St. John's wort); avoid concomitant use. Potentiates P-gp substrates (eg, digoxin); monitor. Potentiates CYP3A4 substrates (eg, atorvastatin) when concomitant Nourianz 40mg; monitor. Efficacy may be decreased by tobacco smoking; see Adults.
Nourianz Adverse Reactions
Adverse Reactions
Dyskinesia (monitor), dizziness, constipation, nausea, hallucination, insomnia; urges/compulsive behaviors.
Nourianz Clinical Trials
See Literature
Nourianz Note
Not Applicable
Nourianz Patient Counseling
See Literature
