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Neupro Generic Name & Formulations
Legal Class
Rx
General Description
Rotigotine 1mg/24hrs, 2mg/24hrs, 3mg/24hrs, 4mg/24hrs, 6mg/24hrs, 8mg/24hrs; transdermal patch; contains sodium metabisulfite.
Pharmacological Class
Dopamine agonist (non-ergot).
How Supplied
Patches—30
Manufacturer
Generic Availability
NO
Neupro Indications
Indications
Idiopathic Parkinson's disease.
Neupro Dosage and Administration
Adult
Apply to clean, dry, intact skin on abdomen, thigh, hip, flank, shoulder, or upper arm. Early-stage: initially 2mg/24hrs patch once daily; may increase weekly by 2mg/24hrs if needed; max 6mg/24hrs once daily. Advanced-stage: initially 4mg/24hrs patch once daily; may increase weekly by 2mg/24hrs if needed; max 8mg/24hrs once daily. Rotate application site (allow 14 days before reapplying to same site). Shave site at least 3 days before application if hairy. Avoid abrupt cessation; reduce by 2mg/24hrs every other day.
Children
Not established.
Neupro Contraindications
Not Applicable
Neupro Boxed Warnings
Not Applicable
Neupro Warnings/Precautions
Warnings/Precautions
Avoid external heat sources. Remove patch before cardioversion, MRI. Consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Sleep disorder. Psychotic disorder. Increased risk of symptomatic hypotension; monitor BP esp. during dose adjustments. Cardiovascular disease. Conditions aggravated by fluid retention (eg, CHF, renal insufficiency); monitor for weight gain. Consider dose reduction or discontinuation if urges/compulsive behaviors develop. Asthma. Sulfite sensitivity. Pre-existing dyskinesia. Potential withdrawal symptoms; monitor during and after discontinuation. Severe hepatic impairment. Pregnancy. Nursing mothers: may inhibit lactation.
Neupro Pharmacokinetics
See Literature
Neupro Interactions
Interactions
Caution with concomitant alcohol, sedating drugs or other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be antagonized by metoclopramide, antipsychotics.
Neupro Adverse Reactions
Adverse Reactions
Nausea, vomiting, somnolence (may be sudden), application site reactions, dizziness, anorexia, hyperhidrosis, insomnia, peripheral edema, dyskinesia; orthostatic hypotension, syncope, hallucinations, psychotic-like behavior, intense urges/compulsions, hypertension, heart rate elevation.
Neupro Clinical Trials
See Literature
Neupro Note
Not Applicable
Neupro Patient Counseling
See Literature
Neupro Generic Name & Formulations
Legal Class
Rx
General Description
Rotigotine 1mg/24hrs, 2mg/24hrs, 3mg/24hrs, 4mg/24hrs, 6mg/24hrs, 8mg/24hrs; transdermal patch; contains sodium metabisulfite.
Pharmacological Class
Dopamine agonist (non-ergot).
How Supplied
Patches—30
Manufacturer
Generic Availability
NO
Neupro Indications
Indications
Moderate to severe primary restless legs syndrome (RLS).
Neupro Dosage and Administration
Adult
Apply to clean, dry, intact skin on abdomen, thigh, hip, flank, shoulder, or upper arm. Initially 1mg/24hrs patch once daily; may increase weekly by 1mg/24hrs if needed; max 3mg/24hrs once daily. Rotate application site (allow 14 days before reapplying to same site). Shave site at least 3 days before application if hairy. Avoid abrupt cessation; reduce by 1mg/24hrs every other day.
Children
Not established.
Neupro Contraindications
Not Applicable
Neupro Boxed Warnings
Not Applicable
Neupro Warnings/Precautions
Warnings/Precautions
Avoid external heat sources. Remove patch before cardioversion, MRI. Consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Sleep disorder. Psychotic disorder. Increased risk of symptomatic hypotension; monitor BP esp. during dose adjustments. Cardiovascular disease. Conditions aggravated by fluid retention (eg, CHF, renal insufficiency); monitor for weight gain. Consider dose reduction or discontinuation if urges/compulsive behaviors develop. Asthma. Sulfite sensitivity. Pre-existing dyskinesia. Potential withdrawal symptoms; monitor during and after discontinuation. Severe hepatic impairment. Pregnancy. Nursing mothers: may inhibit lactation.
Neupro Pharmacokinetics
See Literature
Neupro Interactions
Interactions
Caution with concomitant alcohol, sedating drugs or other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be antagonized by metoclopramide, antipsychotics.
Neupro Adverse Reactions
Adverse Reactions
Nausea, vomiting, somnolence (may be sudden), application site reactions, headache, dizziness, anorexia, hyperhidrosis, insomnia, peripheral edema, dyskinesia; orthostatic hypotension, syncope, hallucinations, psychotic-like behavior, intense urges/compulsions, hypertension, heart rate elevation, augmentation/rebound of RLS symptoms.
Neupro Clinical Trials
See Literature
Neupro Note
Not Applicable
Neupro Patient Counseling
See Literature
