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Namenda Xr Generic Name & Formulations
Legal Class
Rx
General Description
Memantine HCl 7mg, 14mg, 21mg, 28mg; ext-rel caps.
Pharmacological Class
NMDA receptor antagonist.
See Also
How Supplied
Tabs—60; Titration Pak (28 x 5mg + 21 x 10mg)—1; Oral soln—contact supplier; XR caps 7mg, 21mg—30; 14mg, 28mg—30, 90; XR Titration Pak (7 x 7mg + 7 x 14mg + 7 x 21mg + 7 x 28mg)—1
Manufacturer
Generic Availability
YES
Namenda Xr Indications
Indications
Moderate-to-severe dementia of the Alzheimer's type.
Namenda Xr Dosage and Administration
Adult
Do not divide doses. Swallow whole or may open caps and sprinkle on applesauce, then consume entire contents. Initially 7mg once daily; titrate at intervals of at least 1 week in increments of 7mg to target dose of 28mg once daily. Max 28mg once daily. Severe renal impairment (CrCl 5–29mL/min): titrate to target dose of 14mg/day. Switching from immediate-release tabs: give XR caps the day after last dose of immediate-release tabs; see full labeling.
Children
Not established.
Namenda Xr Contraindications
Not Applicable
Namenda Xr Boxed Warnings
Not Applicable
Namenda Xr Warnings/Precautions
Warnings/Precautions
Severe hepatic impairment. Alkalinized urine (eg, renal tubular acidosis, severe UTI) increases memantine serum levels. Seizure disorder. Pregnancy. Nursing mothers.
Namenda Xr Pharmacokinetics
Elimination
Renal. Half-life: ~60–80 hours.
Namenda Xr Interactions
Interactions
Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ, metformin, cimetidine, nicotine, ranitidine, quinidine). Plasma levels may be increased by urinary alkalinizers.
Namenda Xr Adverse Reactions
Adverse Reactions
Headache, dizziness, confusion, diarrhea, constipation, hypertension, pain, somnolence, hallucination, urinary disorders, dyspnea.
Namenda Xr Clinical Trials
See Literature
Namenda Xr Note
Not Applicable
Namenda Xr Patient Counseling
See Literature
