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Namenda Generic Name & Formulations
Legal Class
Rx
General Description
Memantine HCl 5mg, 10mg; tabs.
Pharmacological Class
NMDA receptor antagonist.
See Also
How Supplied
Tabs—60; Titration Pak (28 x 5mg + 21 x 10mg)—1; Oral soln—contact supplier; XR caps 7mg, 21mg—30; 14mg, 28mg—30, 90; XR Titration Pak (7 x 7mg + 7 x 14mg + 7 x 21mg + 7 x 28mg)—1
Manufacturer
Generic Availability
YES
Namenda Indications
Indications
Moderate-to-severe dementia of the Alzheimer's type.
Namenda Dosage and Administration
Adult
Initially 5mg once daily; titrate at intervals of at least 1 week to 5mg twice daily, then to 5mg and 10mg as separate doses, then to 10mg twice daily (prescribe Titration Pak for 1st 4 weeks). Severe renal impairment (CrCl 5–29mL/min): titrate to max 5mg twice daily.
Children
Not established.
Namenda Contraindications
Not Applicable
Namenda Boxed Warnings
Not Applicable
Namenda Warnings/Precautions
Warnings/Precautions
Severe hepatic impairment. Alkalinized urine (eg, renal tubular acidosis, severe UTI) increases memantine serum levels. Seizure disorder. Pregnancy. Nursing mothers.
Namenda Pharmacokinetics
Elimination
Renal. Half-life: ~60–80 hours.
Namenda Interactions
Interactions
Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ, metformin, cimetidine, nicotine, ranitidine, quinidine). Plasma levels may be increased by urinary alkalinizers.
Namenda Adverse Reactions
Adverse Reactions
Headache, dizziness, confusion, diarrhea, constipation, hypertension, pain, somnolence, hallucination, urinary disorders, dyspnea.
Namenda Clinical Trials
See Literature
Namenda Note
Not Applicable
Namenda Patient Counseling
See Literature
