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Mysoline Generic Name & Formulations
Legal Class
Rx
General Description
Primidone 50mg, 250mg; scored tabs.
Pharmacological Class
Barbiturate.
How Supplied
Tabs 50mg—100, 500; 250mg—100, 1000
Manufacturer
Mysoline Indications
Indications
Tonic-clonic, focal and psychomotor seizures.
Mysoline Dosage and Administration
Adult
Initially: 100–125mg at bedtime. Increase every 3 days if needed by 100–125mg daily to 3 times daily on day 7. On day 10, increase to 250mg 3 times daily; max 2g daily in divided doses.
Children
<8yrs: initially 50mg at bedtime. On day 4, increase if needed to 50mg twice daily. On day 7, to 100mg twice daily. On day 10, to 125–250mg 3 times daily. Usual maintenance: 100–250mg 3 times daily or 10–25mg/kg/day in divided doses. ≥8yrs: as adult.
Mysoline Contraindications
Contraindications
Porphyria. Barbiturate hypersensitivity.
Mysoline Boxed Warnings
Not Applicable
Mysoline Warnings/Precautions
Warnings/Precautions
Impaired liver function. Change dose gradually. Monitor blood counts, electrolytes. Pregnancy. Nursing mothers.
Mysoline Pharmacokinetics
See Literature
Mysoline Interactions
Interactions
Potentiated with alcohol and other CNS depressants. Antagonizes oral anticoagulants and contraceptives, steroids, Vit. K and D, griseofulvin, doxycycline. Variable effects with phenytoin, valproic acid, divalproex. Potentiated by MAOIs. Antagonizes tricyclic antidepressants.
Mysoline Adverse Reactions
Adverse Reactions
Drowsiness, ataxia, dizziness, nystagmus, neonatal hemorrhage and withdrawal, nausea, vomiting, rash, megaloblastic anemia sensitive to folic acid, emotional disorders, impotence.
Mysoline Clinical Trials
See Literature
Mysoline Note
Not Applicable
Mysoline Patient Counseling
See Literature
