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Memantine Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Memantine HCl 2mg/mL; sugar-and alcohol-free; peppermint flavor.
Pharmacological Class
NMDA receptor antagonist.
See Also
How Supplied
Tabs—60; Titration Pak (28 x 5mg + 21 x 10mg)—1; Oral soln—contact supplier; XR caps 7mg, 21mg—30; 14mg, 28mg—30, 90; XR Titration Pak (7 x 7mg + 7 x 14mg + 7 x 21mg + 7 x 28mg)—1
Manufacturer
Generic Availability
YES
Memantine Oral Solution Indications
Indications
Moderate-to-severe dementia of the Alzheimer's type.
Memantine Oral Solution Dosage and Administration
Adult
Initially 5mg once daily; titrate at intervals of at least 1 week to 5mg twice daily, then to 5mg and 10mg as separate doses, then to 10mg twice daily (prescribe Titration Pak for 1st 4 weeks). Severe renal impairment (CrCl 5–29mL/min): titrate to max 5mg twice daily.
Children
Not established.
Memantine Oral Solution Contraindications
Not Applicable
Memantine Oral Solution Boxed Warnings
Not Applicable
Memantine Oral Solution Warnings/Precautions
Warnings/Precautions
Severe hepatic impairment. Alkalinized urine (eg, renal tubular acidosis, severe UTI) increases memantine serum levels. Seizure disorder. Pregnancy. Nursing mothers.
Memantine Oral Solution Pharmacokinetics
See Literature
Memantine Oral Solution Interactions
Interactions
Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ, metformin, cimetidine, nicotine, ranitidine, quinidine). Plasma levels may be increased by urinary alkalinizers.
Memantine Oral Solution Adverse Reactions
Adverse Reactions
Headache, dizziness, confusion, diarrhea, constipation, hypertension, pain, somnolence, hallucination, urinary disorders, dyspnea.
Memantine Oral Solution Clinical Trials
See Literature
Memantine Oral Solution Note
Not Applicable
Memantine Oral Solution Patient Counseling
See Literature
