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Lyrica Generic Name & Formulations
Legal Class
CV
General Description
Pregabalin 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg; caps.
Pharmacological Class
Alpha-2 delta ligand.
See Also
How Supplied
Caps—90; Soln—16oz
Manufacturer
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, some results related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's anti-nociceptive and antiseizure effects in animals.
Lyrica Indications
Indications
Fibromyalgia.
Lyrica Dosage and Administration
Adult
Initially 75mg twice daily, may increase to 150mg twice daily within 1 week as tolerated; max 450mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see full labeling); hemodialysis: give supplemental dose after session.
Children
Not established.
Lyrica Contraindications
Not Applicable
Lyrica Boxed Warnings
Not Applicable
Lyrica Warnings/Precautions
Warnings/Precautions
Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. Monitor for new or worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. CHF (w. NYHA Class III/IV status). Ocular conditions. Diabetes (monitor skin integrity). Avoid abrupt cessation (taper over ≥1 week). Pregnancy. Nursing mothers: not recommended.
Lyrica Pharmacokinetics
Absorption
Peak plasma concentration: 1.5 hours (capsules). Oral bioavailability: ≥90%. Steady state: achieved within 24–48 hours.
Distribution
Apparent volume of distribution: ~0.5 L/kg.
Elimination
Renal (90%). Half-life: 6.3 hours.
Lyrica Interactions
Interactions
Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones. Increased risk of angioedema with concomitant ACEIs.
Lyrica Adverse Reactions
Adverse Reactions
Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal (primarily difficulty with concentration/attention); elevated creatine kinase, decreased platelets, PR prolongation, male-mediated teratogenicity; may be tumorigenic. Also in children: increased appetite.
Lyrica Clinical Trials
See Literature
Lyrica Note
Notes
Register patients in North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling (888) 233-2334.
Lyrica Patient Counseling
See Literature
Lyrica Generic Name & Formulations
Legal Class
CV
General Description
Pregabalin 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg; caps.
Pharmacological Class
Alpha-2 delta ligand.
See Also
How Supplied
Caps—90; CR tabs—30; Soln—16oz
Manufacturer
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, some results related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's anti-nociceptive and antiseizure effects in animals.
Lyrica Indications
Indications
Neuropathic pain associated with diabetic peripheral neuropathy (DPN) or spinal cord injury. Postherpetic neuralgia (PHN).
Lyrica Dosage and Administration
Adult
DPN: initially 50mg 3 times daily, may increase to 100mg 3 times daily within 1 week. Spinal cord injury: initially 75mg twice daily, may increase to 150mg twice daily within 1 week, then max 600mg/day after 2 weeks as tolerated. PHN: initially 75mg twice daily or 50mg 3 times daily; max 300mg/day after 1 week then 600mg/day after 2 weeks as tolerated (see full labeling). For all: renal impairment (CrCl <60mL/min): reduce dose (see full labeling); hemodialysis: give supplemental dose after session.
Children
Not established.
Lyrica Contraindications
Not Applicable
Lyrica Boxed Warnings
Not Applicable
Lyrica Warnings/Precautions
Warnings/Precautions
Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. Monitor for new or worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. CHF (w. NYHA Class III/IV status). Ocular conditions. Diabetes (monitor skin integrity). Avoid abrupt cessation (taper over ≥1 week). Pregnancy. Nursing mothers: not recommended.
Lyrica Pharmacokinetics
Absorption
Peak plasma concentration: 1.5 hours (capsules). Oral bioavailability: ≥90%. Steady state: achieved within 24–48 hours.
Distribution
Apparent volume of distribution: ~0.5 L/kg.
Elimination
Renal (90%). Half-life: 6.3 hours.
Lyrica Interactions
Interactions
Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones. Increased risk of angioedema with concomitant ACEIs.
Lyrica Adverse Reactions
Adverse Reactions
Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal (primarily difficulty with concentration/attention); elevated creatine kinase, decreased platelets, PR prolongation, male-mediated teratogenicity; may be tumorigenic. Also in children: increased appetite.
Lyrica Clinical Trials
See Literature
Lyrica Note
Notes
Register patients in North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling (888) 233-2334.
Lyrica Patient Counseling
See Literature
Lyrica Generic Name & Formulations
Legal Class
CV
General Description
Pregabalin 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg; caps.
Pharmacological Class
Alpha-2 delta ligand.
See Also
How Supplied
Caps—90; Soln—16oz
Manufacturer
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, some results related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's anti-nociceptive and antiseizure effects in animals.
Lyrica Indications
Indications
Adjunct in partial onset seizures.
Lyrica Dosage and Administration
Adult
Give in 2–3 divided doses. ≥17yrs: initially 150mg/day; max 600mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see full labeling); hemodialysis: give supplemental dose after session.
Children
<1 month: not established. Give in 2–3 divided doses (3 divided doses for <4yrs). ≥1 month (<30kg): initially 3.5mg/kg/day; max 14mg/kg/day; (≥30kg): initially 2.5mg/kg/day, max 10mg/kg/day (up to 600mg/day). Renal impairment (CrCl <60mL/min): not established.
Lyrica Contraindications
Not Applicable
Lyrica Boxed Warnings
Not Applicable
Lyrica Warnings/Precautions
Warnings/Precautions
Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. Monitor for new or worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. CHF (w. NYHA Class III/IV status). Ocular conditions. Diabetes (monitor skin integrity). Avoid abrupt cessation (taper over ≥1 week). Pregnancy. Nursing mothers: not recommended.
Lyrica Pharmacokinetics
Absorption
Peak plasma concentration: 1.5 hours (capsules). Oral bioavailability: ≥90%. Steady state: achieved within 24–48 hours.
Distribution
Apparent volume of distribution: ~0.5 L/kg.
Elimination
Renal (90%). Half-life: 6.3 hours.
Lyrica Interactions
Interactions
Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones. Increased risk of angioedema with concomitant ACEIs.
Lyrica Adverse Reactions
Adverse Reactions
Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal (primarily difficulty with concentration/attention); elevated creatine kinase, decreased platelets, PR prolongation, male-mediated teratogenicity; may be tumorigenic. Also in children: increased appetite.
Lyrica Clinical Trials
See Literature
Lyrica Note
Notes
Register patients in North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling (888) 233-2334.
Lyrica Patient Counseling
See Literature
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