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Lodosyn Generic Name & Formulations
Legal Class
Rx
General Description
Carbidopa 25mg; scored tabs.
Pharmacological Class
Dopa-decarboxylase inhibitor.
How Supplied
Tabs—100
Manufacturer
Lodosyn Indications
Indications
Parkinsonism (in combination with Sinemet or levodopa).
Lodosyn Dosage and Administration
Adult
≥18yrs: Concomitant Sinemet 10-100: give Lodosyn 25mg with first dose of Sinemet each day; additional 12.5mg or 25mg doses may be given with each dose of Sinemet. Concomitant Sinemet 25-100 or 25-250: give Lodosyn 25mg with any dose of Sinemet as required for optimum therapeutic response. Max total daily dose of carbidopa: 200mg. Patients requiring individual titration of carbidopa and levodopa: initially Lodosyn 25mg 3–4 times daily with concomitant levodopa, starting with max 20-25% of previous or recommended daily dosage of levodopa when given without carbidopa; if patient already receiving levodopa therapy, allow 12hrs to elapse before initiating carbidopa with levodopa. May give Vit. B6 supplement. See full labeling for dosage adjustments, interruption of therapy.
Children
<18yrs: not recommended.
Lodosyn Contraindications
Contraindications
During or within 14 days of nonselective MAOIs. Narrow-angle glaucoma.
Lodosyn Boxed Warnings
Not Applicable
Lodosyn Warnings/Precautions
Warnings/Precautions
With levodopa: Severe cardiovascular or pulmonary disease. Asthma. Renal, hepatic, or endocrine disorders. History of peptic ulcer or MI with residual arrhythmias. Suicidal tendencies. Psychosis. Orthostatic hypotension. Chronic wide-angle glaucoma. Monitor renal, liver, cardiovascular function, intraocular pressure, blood counts during extended therapy. May stain body fluids. Sleep disorders. Impulse control/compulsive behaviors; consider dose reduction or discontinue if occurs. Monitor for melanomas; perform skin exams. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Lodosyn Pharmacokinetics
See Literature
Lodosyn Interactions
Interactions
With levodopa: See Contraindications. Orthostatic hypotension with selegiline, rasigiline, or antihypertensives; may need to adjust dose of antihypertensive. Antagonized by phenothiazines, butyrophenones, risperidone, phenytoin, papaverine. Hypertension, dyskinesia with tricyclic antidepressants. May be antagonized by iron, high protein diets. May cause false (+) urinary ketone test or false (–) urinary glucose (glucose oxidase) test.
Lodosyn Adverse Reactions
Adverse Reactions
With levodopa: Dyskinesia, nausea, hallucinations, confusion, psychological disturbances, depression, dizziness, headache, dream abnormalities, somnolence, sleepiness, dystonia, cardiac arrhythmias, hypotension, dyspnea, on-off phenomenon, back pain, blepharospasm (may indicate excess dosage), hypertension, anticholinergic effects, anorexia, insomnia, leukopenia, renal and liver function disorders, neuroleptic malignant syndrome.
Lodosyn Clinical Trials
See Literature
Lodosyn Note
Not Applicable
Lodosyn Patient Counseling
See Literature
