Keppra Xr Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Mechanism of Action
Keppra Xr Indications
Indications
Keppra Xr Dosage and Administration
Adult
Children
Keppra Xr Contraindications
Not Applicable
Keppra Xr Boxed Warnings
Not Applicable
Keppra Xr Warnings/Precautions
Warnings/Precautions
Monitor for behavioral abnormalities, psychiatric symptoms, emergence or worsening of depression, suicidal ideation, somnolence, fatigue. Hematologic abnormalities: do CBCs in those experiencing significant weakness, pyrexia, recurrent infections, or coagulation disorders. Discontinue if anaphylaxis or angioedema develops. Discontinue at the 1st sign of rash; do not resume if Stevens-Johnson syndrome or toxic epidermal necrolysis is suspected. Evaluate immediately if signs or symptoms of drug reaction with eosinophilia and systemic symptoms (DRESS)/multiorgan hypersensitivity develop; discontinue if alternative etiology cannot be established. Renal impairment. Avoid abrupt cessation. Elderly (consider monitoring renal function). Pregnancy: monitor carefully (esp. during 3rd trimester). Nursing mothers.
Keppra Xr Pharmacokinetics
Absorption
Peak plasma concentration occurs in about 4 hours. Intake of a high fat, high calorie breakfast before the administration of extended-release levetiracetam tablets resulted in a higher peak concentration, and longer median time to peak.
Distribution
Volume of distribution is close to the volume of intracellular and extracellular water. Plasma protein bound: <10%.
Elimination
Renal (66%). Plasma half-life: 7±1 hour. Total body clearance: 0.96 mL/min/kg. Renal clearance: 0.6 mL/min/kg.
Keppra Xr Interactions
Not Applicable
Keppra Xr Adverse Reactions
Adverse Reactions
Keppra Xr Clinical Trials
See Literature
Keppra Xr Note
Notes
Keppra Xr Patient Counseling
See Literature
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