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Galantamine Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Galantamine (as HBr) 4mg/mL.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (benzazepine deriv).
See Also
How Supplied
Tabs, soln—contact supplier; ER caps—30
Manufacturer
Galantamine Oral Solution Indications
Indications
Mild to moderate Alzheimer's dementia.
Galantamine Oral Solution Dosage and Administration
Adult
Give with AM & PM meals. Initially 4mg twice daily; if well-tolerated, increase to maintenance dose 8mg twice daily (16mg/day) after minimum of 4 weeks; may attempt further increase to 12mg twice daily (24mg/day) after minimum of 4 weeks. Re-titrate if interrupted for >3 days. Moderate hepatic or renal impairment (CrCl 9–59mL/min): usual max 16mg/day.
Children
Not established.
Galantamine Oral Solution Contraindications
Not Applicable
Galantamine Oral Solution Boxed Warnings
Not Applicable
Galantamine Oral Solution Warnings/Precautions
Warnings/Precautions
Discontinue at the first sign of skin rash, unless not drug-related; consider alternative therapy if serious skin reactions occur. Conduction disorders (eg, bradycardia, AV block). History of ulcer disease. Bladder outflow obstruction. Asthma. COPD. Seizures. Monitor for active or occult GI bleed, respiratory or neurological effects, and patient's weight. Maintain adequate hydration. Severe hepatic or renal impairment (CrCl <9mL/min): not recommended. Pregnancy. Nursing mothers.
Galantamine Oral Solution Pharmacokinetics
See Literature
Galantamine Oral Solution Interactions
Interactions
Potentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate. May be potentiated by ketoconazole, cimetidine, paroxetine, fluoxetine, erythromycin, possibly others that affect CYP2D6 or CYP3A4. Monitor for GI bleed with NSAIDs.
Galantamine Oral Solution Adverse Reactions
Adverse Reactions
Nausea, vomiting, diarrhea, dizziness, headache, decreased appetite, anorexia, weight loss, syncope, bradycardia, heart block, seizures; serious skin reactions (eg, Stevens-Johnson syndrome).
Galantamine Oral Solution Clinical Trials
See Literature
Galantamine Oral Solution Note
Notes
Formerly known under the brand name Razadyne.
Galantamine Oral Solution Patient Counseling
See Literature
