Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Galantamine Generic Name & Formulations
Legal Class
Rx
General Description
Galantamine (as HBr) 4mg, 8mg, 12mg; tabs.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (benzazepine deriv).
See Also
How Supplied
Tabs, soln—contact supplier; ER caps—30
Manufacturer
Galantamine Indications
Indications
Mild to moderate Alzheimer's dementia.
Galantamine Dosage and Administration
Adult
Give with AM & PM meals. Initially 4mg twice daily; if well-tolerated, increase to maintenance dose 8mg twice daily (16mg/day) after minimum of 4 weeks; may attempt further increase to 12mg twice daily (24mg/day) after minimum of 4 weeks. Re-titrate if interrupted for >3 days. Moderate hepatic or renal impairment (CrCl 9–59mL/min): usual max 16mg/day.
Children
Not established.
Galantamine Contraindications
Not Applicable
Galantamine Boxed Warnings
Not Applicable
Galantamine Warnings/Precautions
Warnings/Precautions
Discontinue at the first sign of skin rash, unless not drug-related; consider alternative therapy if serious skin reactions occur. Conduction disorders (eg, bradycardia, AV block). History of ulcer disease. Bladder outflow obstruction. Asthma. COPD. Seizures. Monitor for active or occult GI bleed, respiratory or neurological effects, and patient's weight. Maintain adequate hydration. Severe hepatic or renal impairment (CrCl <9mL/min): not recommended. Pregnancy. Nursing mothers.
Galantamine Pharmacokinetics
See Literature
Galantamine Interactions
Interactions
Potentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate. May be potentiated by ketoconazole, cimetidine, paroxetine, fluoxetine, erythromycin, possibly others that affect CYP2D6 or CYP3A4. Monitor for GI bleed with NSAIDs.
Galantamine Adverse Reactions
Adverse Reactions
Nausea, vomiting, diarrhea, dizziness, headache, decreased appetite, anorexia, weight loss, syncope, bradycardia, heart block, seizures; serious skin reactions (eg, Stevens-Johnson syndrome).
Galantamine Clinical Trials
See Literature
Galantamine Note
Notes
Formerly known under the brand name Razadyne.
Galantamine Patient Counseling
See Literature
