Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Gabitril Generic Name & Formulations
Legal Class
Rx
General Description
Tiagabine HCl 2mg, 4mg, 12mg, 16mg; tabs.
Pharmacological Class
GABA reuptake inhibitor.
How Supplied
Tabs—30
Manufacturer
Generic Availability
YES
Gabitril Indications
Indications
Adjunct in partial seizures.
Gabitril Dosage and Administration
Adult
Take with food. Use lower doses and titrate slower if not on concomitant enzyme-inducing drug(s). 12–18yrs: 4mg once daily for 1 week; may increase to 8mg/day in 2 divided doses for 1 week; then may increase by 4–8mg weekly to clinical response or up to 32mg/day in 2–4 divided doses. ≥18yrs: 4mg once daily for 1 week; may increase by 4–8mg weekly to clinical response or up to 56mg/day in 2–4 divided doses.
Children
Not established.
Gabitril Contraindications
Not Applicable
Gabitril Boxed Warnings
Not Applicable
Gabitril Warnings/Precautions
Warnings/Precautions
Hepatic impairment: reduce dose. Reduce dose or discontinue if generalized weakness occurs. Adjust dose if spike and wave discharges on EEG with cognitive or neuropsychiatric events occur. Discontinue and evaluate if seizures develop in nonepileptic patients during therapy. Suicidal tendencies (monitor). Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Gabitril Pharmacokinetics
See Literature
Gabitril Interactions
Interactions
CNS depression may be potentiated by alcohol, triazolam, other CNS depressants. Tiagabine levels reduced by enzyme inducers (eg, phenytoin, carbamazepine, primidone, phenobarbital), St. John's wort. May interact with valproate (monitor). May affect or be affected by highly protein bound drugs.
Gabitril Adverse Reactions
Adverse Reactions
Dizziness, asthenia, somnolence, fatigue, GI upset/pain, nervousness, tremor, abdominal pain, concentration difficulties, dysphasia, confusion, other CNS effects, serious rash; possible long-term ophthalmologic effects.
Gabitril Clinical Trials
See Literature
Gabitril Note
Not Applicable
Gabitril Patient Counseling
See Literature
