Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Extavia Generic Name & Formulations
Legal Class
Rx
General Description
Interferon beta-1b 0.3mg/vial; lyophilized pwd for SC inj after reconstitution; preservative-free; contains albumin (human), mannitol.
Pharmacological Class
Immunomodulator.
How Supplied
Single-use vials—15 (w. prefilled diluent syringe, supplies)
Manufacturer
Generic Availability
NO
Mechanism of Action
The mechanism of action of interferon beta-1b in patients with MS is unknown.
Extavia Indications
Indications
Relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
Extavia Dosage and Administration
Adult
Pre-medicate with analgesics and/or antipyretics on treatment days to ameliorate flu-like symptoms. Rotate inj sites. ≥18yrs: initially 0.0625mg SC every other day; increase by 25% every 2 weeks to target dose of 0.25mg SC every other day.
Children
<18yrs: not established.
Extavia Contraindications
Not Applicable
Extavia Boxed Warnings
Not Applicable
Extavia Warnings/Precautions
Warnings/Precautions
Monitor for hepatic injury; consider discontinuing if elevated transaminase levels or jaundice occurs. Depression. Suicidal ideation. Pre-existing CHF: monitor for worsening cardiac function at initiation and during treatment. Discontinue if thrombotic microangiopathy or signs/symptoms of drug-induced lupus erythematosus occurs. Myelosuppression. Monitor CBCs, differential, platelets, chemistries, liver function tests (at 1, 3, and 6 months then periodically). Risk for pulmonary arterial hypertension (PAH); evaluate and discontinue if PAH is confirmed. Latex allergy (diluent). Pregnancy. Nursing mothers.
Extavia Pharmacokinetics
See Literature
Extavia Interactions
Interactions
Risk of hepatic injury with concomitant hepatotoxic drugs or other products (eg, alcohol).
Extavia Adverse Reactions
Adverse Reactions
Inj site reactions (necrosis, cellulitis, abscess, inflammation, pain), lymphopenia, flu-like symptoms, myalgia, leukopenia, neutropenia, increased liver enzymes, headache, hypertonia, rash, insomnia, abdominal pain, asthenia; rare: hepatic injury, anaphylaxis (discontinue if occurs), possible seizures.
Extavia Clinical Trials
See Literature
Extavia Note
Not Applicable
Extavia Patient Counseling
See Literature
Images
