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Exservan Generic Name & Formulations
Legal Class
Rx
General Description
Riluzole 50mg; oral films.
Pharmacological Class
Benzothiazole.
How Supplied
Oral films—60
Manufacturer
Generic Availability
NO
Exservan Indications
Indications
Amyotrophic lateral sclerosis (ALS).
Exservan Dosage and Administration
Adult
Take ≥1hr before or 2hrs after a meal. Dissolve on tongue and swallow. 50mg twice daily.
Children
Not established.
Exservan Contraindications
Not Applicable
Exservan Boxed Warnings
Not Applicable
Exservan Warnings/Precautions
Warnings/Precautions
Monitor for hepatic injury monthly for the first 3 months, and periodically thereafter. Measure serum aminotransferases before and during treatment. If ALT >5×ULN: not recommended. Discontinue if liver dysfunction evident (eg, elevated bilirubin). Risk of neutropenia: monitor for febrile illness. Discontinue immediately if interstitial lung disease develops. Japanese patients (higher drug concentration/adverse reactions). Hepatic impairment. Elderly. Pregnancy. Nursing mothers.
Exservan Pharmacokinetics
See Literature
Exservan Interactions
Interactions
May be potentiated by strong or moderate CYP1A2 inhibitors (eg, ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, oral contraceptives, thiabendazole, vemurafenib, zileuton). May be antagonized by CYP1A2 inducers. Increased risk of hepatotoxicity with concomitant other hepatotoxic agents (eg, allopurinol, methyldopa, sulfasalazine).
Exservan Adverse Reactions
Adverse Reactions
Oral hypoesthesia, asthenia, nausea, decreased lung function, hypertension, abdominal pain; elevated ALTs, severe neutropenia, interstitial lung disease, hypersensitivity pneumonitis.
Exservan Clinical Trials
See Literature
Exservan Note
Not Applicable
Exservan Patient Counseling
See Literature
