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Exelon Patch Generic Name & Formulations
Legal Class
Rx
General Description
Rivastigmine 4.6mg/24hrs, 9.5mg/24hrs, 13.3mg/24hrs; transdermal system.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (carbamate deriv).
See Also
How Supplied
Caps—contact supplier; Patches—30
Manufacturer
Generic Availability
YES
Exelon Patch Indications
Indications
Treatment of dementia of the Alzheimer's type.
Exelon Patch Dosage and Administration
Adult
Apply to clean, dry, hairless intact skin. Rotate application site (allow 14 days before reapplying to same site). Initially apply one 4.6mg/24hrs patch once daily; if tolerated, may increase to 9.5mg/24hrs patch after 4 weeks at previous dose; can further be increased to max 13.3mg/24hrs dose. Mild to moderate: usually 9.5mg/24hrs or 13.3mg/24hrs once daily. Severe: usually 13.3mg/24hrs once daily. If dosing interrupted for >3 days, restart with 4.6mg/24hrs patch and retitrate. Mild to moderate hepatic impairment: initial and max dose 4.6mg/24hrs patch. Low body wt. (<50kg): monitor for toxicities and consider reducing maintenance dose to 4.6mg/24hrs patch. Switching from capsules: see full labeling.
Children
<18yrs: not recommended.
Exelon Patch Contraindications
Contraindications
Patches: previous history of application site reactions suggestive of allergic contact dermatitis (in the absence of negative allergy testing).
Exelon Patch Boxed Warnings
Not Applicable
Exelon Patch Warnings/Precautions
Warnings/Precautions
Monitor for nausea, vomiting, anorexia, weight loss, GI bleed. Sick sinus syndrome, other supraventricular conduction disturbances. Seizures. History or risk of ulcers. Urinary obstruction. Asthma. COPD. Discontinue if disseminated allergic dermatitis occurs. Renal or hepatic impairment. Pregnancy. Nursing mothers.
Exelon Patch Pharmacokinetics
See Literature
Exelon Patch Interactions
Interactions
Concomitant metoclopramide, beta-blockers, cholinomimetics, anticholinergics: not recommended. May potentiate succinylcholine-type muscle relaxants. Monitor for GI bleed with NSAIDs.
Exelon Patch Adverse Reactions
Adverse Reactions
Nausea, vomiting, anorexia, dyspepsia, asthenia, diarrhea, abdominal pain, dizziness, weight loss, tremor, cholinergic effects; also, patches: application site reactions, allergic contact dermatitis (discontinue if suspected or no improvements within 48hrs after removal; or consider switching to oral form only after negative allergy testing; monitor).
Exelon Patch Clinical Trials
See Literature
Exelon Patch Note
Not Applicable
Exelon Patch Patient Counseling
See Literature
Exelon Patch Generic Name & Formulations
Legal Class
Rx
General Description
Rivastigmine 4.6mg/24hrs, 9.5mg/24hrs, 13.3mg/24hrs; transdermal system.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (carbamate deriv).
See Also
How Supplied
Caps—contact supplier; Patches—30
Manufacturer
Exelon Patch Indications
Indications
Mild to moderate dementia associated with Parkinson's disease.
Exelon Patch Dosage and Administration
Adult
Take with food in the AM and PM. Initially 1.5mg twice daily; if tolerated, may increase by 1.5mg twice daily at intervals of at least 4 weeks. Usual range: 3–12mg/day; max 12mg/day. If dose is not tolerated, suspend for several doses and restart at same or next lower dose. If stopped for >3 days restart at 1.5mg twice daily and retitrate. Moderate to severe renal or mild to moderate hepatic impairment: use lower doses. Low body wt. (<50kg): monitor for toxicities and consider reducing dose. Patch: Apply to clean, dry, hairless intact skin. Rotate application site (allow 14 days before reapplying to same site). Initially apply one 4.6mg/24hrs patch once daily; if tolerated, may increase to 9.5mg/24hrs patch after 4 weeks at previous dose; can further be increased to max 13.3mg/24hrs dose. If dosing interrupted for >3 days, restart with 4.6mg/24hrs patch and retitrate. Mild to moderate hepatic impairment: initial and max dose 4.6mg/24hrs patch. Low body wt. (<50kg): monitor for toxicities and consider reducing maintenance dose to 4.6mg/24hrs patch. Switching from capsules: see full labeling.
Children
<18yrs: not recommended.
Exelon Patch Contraindications
Contraindications
Patches: previous history of application site reactions suggestive of allergic contact dermatitis (in the absence of negative allergy testing).
Exelon Patch Boxed Warnings
Not Applicable
Exelon Patch Warnings/Precautions
Warnings/Precautions
Monitor for nausea, vomiting, anorexia, weight loss, GI bleed. Sick sinus syndrome, other supraventricular conduction disturbances. Seizures. History or risk of ulcers. Urinary obstruction. Asthma. COPD. Discontinue if disseminated allergic dermatitis occurs. Renal or hepatic impairment. Pregnancy. Nursing mothers.
Exelon Patch Pharmacokinetics
See Literature
Exelon Patch Interactions
Interactions
Concomitant metoclopramide, beta-blockers, cholinomimetics, anticholinergics: not recommended. May potentiate succinylcholine-type muscle relaxants. Monitor for GI bleed with NSAIDs.
Exelon Patch Adverse Reactions
Adverse Reactions
Nausea, vomiting, anorexia, dyspepsia, asthenia, diarrhea, abdominal pain, dizziness, weight loss, tremor, cholinergic effects; also, patches: application site reactions, allergic contact dermatitis (discontinue if suspected or no improvements within 48hrs after removal; or consider switching to oral form only after negative allergy testing; monitor).
Exelon Patch Clinical Trials
See Literature
Exelon Patch Note
Not Applicable
Exelon Patch Patient Counseling
See Literature
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