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Dhivy Generic Name & Formulations
Legal Class
Rx
General Description
Carbidopa, levodopa 25mg/100mg; functionally scored tabs.
Pharmacological Class
Dopa-decarboxylase inhibitor + dopamine precursor.
How Supplied
Tabs—100
Manufacturer
Generic Availability
NO
Dhivy Indications
Indications
Treatment of Parkinson’s disease, post-encephalitic parkinsonism, and symptomatic parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.
Dhivy Dosage and Administration
Adult
Individualize. Initially one tab (25mg/100mg) 3 times daily; may increase by up to one whole tab every day or every other day as needed; max 8 whole tabs daily.
Children
Not established.
Dhivy Contraindications
Contraindications
During or within 14 days of nonselective MAOIs (eg, phenelzine, linezolid, tranylcypromine).
Dhivy Boxed Warnings
Boxed Warning
Dhivy Warnings/Precautions
Warnings/Precautions
Sleep disorders; consider discontinuing if significant daytime sleepiness occurs. History of MI with residual arrhythmias; monitor cardiac function. Risk of hallucinations and psychosis. Major psychotic disorder: not recommended. Depression. Suicidal tendencies. Impulse control/compulsive behaviors; consider dose reduction or discontinuation if develops. Peptic ulcer. Glaucoma; monitor IOP. Withdrawal-emergent hyperpyrexia or confusion: avoid sudden discontinuation or rapid dose reduction. Pregnancy. Nursing mothers.
Dhivy Pharmacokinetics
See Literature
Dhivy Interactions
Interactions
See Contraindications. Concomitant dopamine-depleting agents (eg, reserpine, tetrabenazine) or other drugs known to deplete monoamine stores: not recommended. Antagonized by dopamine D2 receptor antagonists (eg, phenothiazines, butyrophenones, risperidone, metoclopramide), isoniazid, iron salts. Delayed absorption with high-protein diet, high-fat, high-calorie meals or excessive acidity. May cause false (+) urinary ketone test or false (–) urinary glucose (glucose oxidase) test.
Dhivy Adverse Reactions
Adverse Reactions
Dyskinesias (eg, choreiform, dystonic), other involuntary movements, nausea; cardiovascular ischemic events, lab abnormalities.
Dhivy Clinical Trials
See Literature
Dhivy Note
Not Applicable
Dhivy Patient Counseling
See Literature
