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Comtan Generic Name & Formulations
Legal Class
Rx
General Description
Entacapone 200mg; tabs.
Pharmacological Class
COMT inhibitor.
How Supplied
Tabs—100
Manufacturer
Comtan Indications
Indications
Adjunct to levodopa/ carbidopa in patients with idiopathic Parkinson's disease and end-of-dose wearing off.
Comtan Dosage and Administration
Adult
200mg with each dose of levodopa/carbidopa, up to 8 times daily.
Children
Not established.
Comtan Contraindications
Not Applicable
Comtan Boxed Warnings
Not Applicable
Comtan Warnings/Precautions
Warnings/Precautions
Dyskinesias. Pre-existing somnolence or sleep disorders. Major psychotic disorder: not recommended. Impulse control disorders; consider dose reduction or discontinue if occurs. Perform skin exams to monitor for melanoma. Discontinue if prolonged diarrhea suspected. Hepatic impairment. Biliary obstruction. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.
Comtan Pharmacokinetics
See Literature
Comtan Interactions
Interactions
Nonselective MAOIs: not recommended. Consider reducing levodopa dose. Potentiates CNS depression with alcohol, other CNS depressants. Chelates iron. Cardiac effects with drugs metabolized by COMT (eg, epinephrine, isoproterenol, norepinephrine, dopamine, dobutamine, methyldopa, apomorphine, isoetherine, bitolterol). Caution with drugs that interfere with biliary excretion, glucuronidation, intestinal beta-glucuronidase (eg, probenecid, cholestyramine, erythromycin, rifampicin, ampicillin, chloramphenicol). Monitor INR with warfarin. Reduced efficacy with some antipsychotics.
Comtan Adverse Reactions
Adverse Reactions
Dyskinesia, nausea, urine discoloration, hyperkinesia, diarrhea, abdominal pain, vomiting, dry mouth, back pain, dyspnea, somnolence, anxiety, sweating, purpura, asthenia, taste perversion; rarely: orthostatic hypotension, syncope, hallucinations, rhabdomyolysis, hyperpyrexia and confusion upon withdrawal.
Comtan Clinical Trials
See Literature
Comtan Note
Not Applicable
Comtan Patient Counseling
See Literature
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