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Celontin Generic Name & Formulations
Legal Class
Rx
General Description
Methsuximide 300mg; caps.
Pharmacological Class
Succinimide.
How Supplied
Caps—100
Manufacturer
Celontin Indications
Indications
Absence (petit mal) seizures refractory to other drugs.
Celontin Dosage and Administration
Adults and Children
Individualize. Initially 300mg once daily for the 1st week; may increase at weekly intervals by 300mg/day for 3 weeks based on response; max 1.2g daily. May be administered with other anticonvulsants.
Celontin Contraindications
Not Applicable
Celontin Boxed Warnings
Not Applicable
Celontin Warnings/Precautions
Warnings/Precautions
Monitor blood counts periodically, esp. if signs/symptoms of infection develop. Hepatic or renal impairment; monitor urine and liver function tests. Monitor for new or worsening depression, suicidal thoughts and/or unusual changes in behavior; withdraw gradually if occur. May increase frequency of grand mal seizures when used alone in mixed seizure type. Avoid abrupt cessation. Pregnancy.
Celontin Pharmacokinetics
See Literature
Celontin Interactions
Interactions
May potentiate phenytoin, phenobarbital; monitor periodically.
Celontin Adverse Reactions
Adverse Reactions
Nausea, vomiting, diarrhea, weight loss, abdominal pain, constipation, blood dyscrasias, confusion, depression, drowsiness, ataxia, dizziness, rash, urticaria, hyperemia, proteinuria, hematuria; rare: SLE, suicidal ideation, psychosis.
Celontin Clinical Trials
See Literature
Celontin Note
Not Applicable
Celontin Patient Counseling
See Literature
