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Benztropine Injection Generic Name & Formulations
Legal Class
Rx
General Description
Benztropine mesylate 1mg/mL; soln for IM or IV inj.
Pharmacological Class
Anticholinergic.
See Also
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
Benztropine mesylate possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.
Benztropine Injection Indications
Indications
Adjunct in Parkinsonism, drug-induced extrapyramidal disorders.
Benztropine Injection Dosage and Administration
Adult
Parkinsonism: initially 0.5–1mg at bedtime. May increase by 0.5mg at 5–6 day intervals; max 6mg daily. Extrapyramidal disorders: 1–4mg 1–2 times daily. Acute dystonic reactions: 1–2mg IM or IV.
Children
See Contraindications. Use cautiously in older children.
Benztropine Injection Contraindications
Contraindications
Children <3yrs old.
Benztropine Injection Boxed Warnings
Not Applicable
Benztropine Injection Warnings/Precautions
Warnings/Precautions
Tardive dyskinesia: not recommended. Narrow-angle glaucoma. Tachycardia. Psychosis. Prostatic hypertrophy. GI or GU obstruction. Chronically ill. Alcoholics. CNS disease. Exposure to extreme heat. Elderly. Pregnancy.
Benztropine Injection Pharmacokinetics
Elimination
Renal. Half-life: ~36 hours.
Benztropine Injection Interactions
Interactions
Paralytic ileus, hyperthermia, heat stroke with phenothiazines, tricyclic antidepressants. Antagonizes psychotropics.
Benztropine Injection Adverse Reactions
Adverse Reactions
Anticholinergic and antihistaminic effects, weakness, confusion, anhidrosis, excitement, GI upset, depression, lethargy, heat stroke, dysuria, toxic psychosis, rash.
Benztropine Injection Clinical Trials
See Literature
Benztropine Injection Note
Notes
Formerly known under the brand name Cogentin.
Benztropine Injection Patient Counseling
See Literature
