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Adlarity Generic Name & Formulations
Legal Class
Rx
General Description
Donepezil 5mg/day, 10mg/day; transdermal system.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (piperidine deriv).
How Supplied
Patch—4
Manufacturer
Generic Availability
NO
Adlarity Indications
Indications
Alzheimer's dementia.
Adlarity Dosage and Administration
Adult
Apply to clean, dry, intact skin on the back (avoiding the spine). If needed, may apply to the upper buttocks or upper outer thigh. Press down firmly for 30secs. Do not use if patch is damaged, cut, or altered. Rotate application site every 2 weeks. Initially 5mg/day once weekly; may increase to max 10mg/day after 4–6 weeks. Replace the patch after 7 days. Switching from donepezil oral forms: see full labeling.
Children
Not established.
Adlarity Contraindications
Contraindications
History of allergic contact dermatitis with previous use.
Adlarity Boxed Warnings
Not Applicable
Adlarity Warnings/Precautions
Warnings/Precautions
Application-site skin reactions. Use during anesthesia. Cardiac conduction abnormalities. Peptic ulcer. Monitor for GI bleeding. Bladder outflow obstruction. Seizures. Asthma or COPD. Avoid long exposure to external heat. Pregnancy. Nursing mothers.
Adlarity Pharmacokinetics
See Literature
Adlarity Interactions
Interactions
Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, similar neuromuscular blocking agents, other cholinesterase inhibitors, or cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed.
Adlarity Adverse Reactions
Adverse Reactions
Nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, anorexia, ecchymosis; allergic contact dermatitis.
Adlarity Clinical Trials
See Literature
Adlarity Note
Not Applicable
Adlarity Patient Counseling
See Literature
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