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Zanaflex Capsules Generic Name & Formulations
Legal Class
Rx
General Description
Tizanidine HCl 2mg, 4mg, 6mg; caps.
Pharmacological Class
Alpha-2 agonist.
See Also
How Supplied
Tabs, caps—150
Manufacturer
Zanaflex Capsules Indications
Indications
Muscle spasticity (due to its short duration of action reserve for when relief is most important).
Zanaflex Capsules Dosage and Administration
Adult
Initially: usually 4mg, may increase by 2–4mg as needed every 6–8 hrs to a max of 3 doses in 24hrs; max 12mg/dose and 36mg/day. Renal impairment (CrCl <25mL/min): reduce dose. May sprinkle contents of capsules on applesauce (may affect absorption). Tabs and caps not bioequivalent under fed conditions. See full labeling.
Children
Not established.
Zanaflex Capsules Contraindications
Contraindications
Concomitant fluvoxamine, ciprofloxacin.
Zanaflex Capsules Boxed Warnings
Not Applicable
Zanaflex Capsules Warnings/Precautions
Warnings/Precautions
Hepatic dysfunction. Monitor ophthalmic and liver function (aminotransferases at baseline, 1, 3, 6 months, then periodically) and for orthostatic hypotension. Renal dysfunction. Cardiovascular disease. Avoid abrupt cessation. Elderly. Labor & delivery. Pregnancy. Nursing mothers.
Zanaflex Capsules Pharmacokinetics
See Literature
Zanaflex Capsules Interactions
Interactions
Avoid other α2-agonists (eg, clonidine). Hypotension possible with other antihypertensives. Avoid concomitant use with other CYP1A2 inhibitors (eg, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, other fluoroquinolones, oral contraceptives, acyclovir, ticlopidine, zileuton); if clinically necessary, use caution. May potentiate CNS depression with alcohol, baclofen, benzodiazepines, other CNS depressants.
Zanaflex Capsules Adverse Reactions
Adverse Reactions
Dry mouth, somnolence, asthenia, dizziness, UTI, constipation, liver injury or elevated liver enzymes, vomiting, speech disorder, blurred vision, dyskinesia, nervousness, pharyngitis, hypotension, bradycardia, hallucinations/psychosis.
Zanaflex Capsules Clinical Trials
See Literature
Zanaflex Capsules Note
Not Applicable
Zanaflex Capsules Patient Counseling
See Literature
