Xiaflex

See full labeling for injection and finger extension procedure. 0.58mg per injection into a palpable cord with a contracture of a metacarpophalangeal joint (MP) or a proximal interphalangeal (PIP) joint. Approx. 24–72hrs after inj, perform finger extension procedure if contracture persists to facilitate cord disruption. Four weeks after inj and finger extension procedure, if a MP or PIP contracture remains, the cord may be re-injected with a single dose of 0.58mg and finger extension procedure repeated (approx. 24–72hrs after inj). Injections and finger extension procedures may be given up to 3 times per cord at approx. 4-week intervals. May inject up to 2 palpable cords affecting 2 joints or 1 palpable cord affecting 2 joints in same finger at 2 locations during the same visit; if other palpable cords with MP or PIP joint contractures, may inject at other treatment visits approx. 4 weeks apart.

See full labeling for injection and penile modeling procedure. 0.58mg per injection into a Peyronie's plaque; max 4 treatment cycles at approx. 6-week intervals. If more than one plaque present, inject into plaque causing the curvature deformity. Each treatment cycle consists of 2 injection procedures and 1 penile modeling procedure. Perform 2^nd injection procedure 1–3 days after the first, then perform penile modeling procedure 1–3 days after 2^nd injection of the treatment cycle. Treatment course = max 8 injection procedures + 4 penile modeling procedures. If curvature deformity is <15 degrees after the 1^st, 2^nd, or 3^rd cycle, or if further treatment is not clinically indicated, then subsequent cycles should not be administered.