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Trivisc Generic Name & Formulations
Legal Class
Rx
General Description
Sodium hyaluronate 10mg/mL; soln for intra-articular inj.
Pharmacological Class
Hyaluronan.
How Supplied
Single-use prefilled syringe—1
Manufacturer
Generic Availability
NO
Trivisc Indications
Indications
Treatment of pain in osteoarthritis of the knee in patients who have failed nonpharmacologic therapy and simple analgesics (eg, acetaminophen).
Trivisc Dosage and Administration
Adult
Remove joint effusion, if present, before inj. Give as a single intra-articular inj. >21yrs: 2.5mL in one knee only at weekly intervals for 3 weeks. If bilateral, use separate syringes for each knee. May use SC lidocaine or similar local anesthetic prior to inj.
Children
≤21yrs: not established.
Trivisc Contraindications
Contraindications
Knee joint infections. Skin diseases in area of the inj site.
Trivisc Boxed Warnings
Not Applicable
Trivisc Warnings/Precautions
Warnings/Precautions
Effectiveness of a single treatment cycle of <3 injections or repeated treatment cycles: not established. Advise patients to avoid strenuous or prolonged weight-bearing activities for approx. 48hrs following inj. Pregnancy, nursing mothers: not established.
Trivisc Pharmacokinetics
See Literature
Trivisc Interactions
Interactions
Avoid use of disinfectants containing quaternary ammonium salts; hyaluronan can precipitate in their presence. Concomitant other intra-articular inj: not established.
Trivisc Adverse Reactions
Adverse Reactions
Inj site pain, allergic reaction, arthralgia, bleeding at the inj site, bleeding, heaviness; transient knee inflammation.
Trivisc Clinical Trials
See Literature
Trivisc Note
Not Applicable
Trivisc Patient Counseling
See Literature
