Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Skelid Generic Name & Formulations
Legal Class
Rx
General Description
Tiludronate disodium 240mg (equivalent to tiludronate acid 200mg); tabs.
Pharmacological Class
Bisphosphonate.
How Supplied
Tabs (200mg)—56
Manufacturer
Skelid Indications
Indications
Treatment of Paget's disease of bone (osteitis deformans) in patients (1) who have a level of serum alkaline phosphatase at least twice the upper limit of normal, or (2) who are symptomatic, or (3) who are at risk for future complications of their disease.
Skelid Dosage and Administration
Adult
Take with 6–8oz of plain water on an empty stomach. 400mg once daily for 3 months. Do not lie down for at least 30 minutes.
Children
Not recommended.
Skelid Contraindications
Contraindications
Inability to stand or sit upright for at least 30 minutes.
Skelid Boxed Warnings
Not Applicable
Skelid Warnings/Precautions
Warnings/Precautions
Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Severe renal impairment (CrCl <30mL/min): not recommended. Ensure adequate Vit. D and calcium intake. Pregnancy (Cat.C). Nursing mothers.
Skelid Pharmacokinetics
See Literature
Skelid Interactions
Interactions
Calcium, aluminum, magnesium, other divalent cations reduce absorption (separate dosing by at least 2hrs). Caution with aspirin, NSAIDs, other GI irritants. Potentiated by indomethacin, separate dosing by 2hrs.
Skelid Adverse Reactions
Adverse Reactions
GI upset; musculoskeletal pain (may be severe), esophagitis; esophageal ulcer, stricture, or erosion, jaw osteonecrosis; rarely: gastric or duodenal ulcer.
Skelid Clinical Trials
See Literature
Skelid Note
Not Applicable
Skelid Patient Counseling
See Literature
