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Probenecid + Colchicine Generic Name & Formulations
Legal Class
Rx
General Description
Probenecid 500mg, colchicine 0.5mg; scored tabs.
Pharmacological Class
Uricosuric + antiinflammatory.
How Supplied
Contact supplier.
Manufacturer
Probenecid + Colchicine Indications
Indications
Chronic gouty arthritis.
Probenecid + Colchicine Dosage and Administration
Adult
1 tab daily for 1 week, then 1 tab twice daily thereafter. Renal impairment, dose adjustments: see literature.
Children
Not recommended.
Probenecid + Colchicine Contraindications
Contraindications
Acute gouty attack. Blood dyscrasias. Uric acid kidney stones. Children <2 yrs of age. Pregnancy. Concomitant salicylates (antagonizes uricosuric effect).
Probenecid + Colchicine Boxed Warnings
Not Applicable
Probenecid + Colchicine Warnings/Precautions
Warnings/Precautions
History of peptic ulcer. Spastic colon. GI, renal, hepatic, or hematological disorders. G6PD deficiency. Monitor blood counts in long-term therapy. Maintain adequate hydration. Alkalization of urine may be required. Debilitated. Elderly. Nursing mothers.
Probenecid + Colchicine Pharmacokinetics
See Literature
Probenecid + Colchicine Interactions
Interactions
Affects renal clearance of many drugs (esp. penicillins). Potentiates methotrexate (monitor and reduce methotrexate dose). May potentiate thiopental, ketamine, NSAIDs, oral sulfonylureas, acetaminophen, lorazepam, rifampin, other sulfonamides. Pyrazinamide antagonizes uricosuric effect. May cause falsely high readings of theophylline levels, or false (+) RBC or hemoglobin in urine.
Probenecid + Colchicine Adverse Reactions
Adverse Reactions
Headache, dizziness, GI upset, diarrhea, urinary frequency, sore gums, uric acid kidney stones, dermatitis, hematuria, renal colic, fever, peripheral neuritis, myopathy, anemia, blood dyscrasias, hemolytic anemia, purpura, bone marrow depression; rare: severe allergic reactions, anaphylaxis.
Probenecid + Colchicine Clinical Trials
See Literature
Probenecid + Colchicine Note
Notes
Formerly known under the brand name Colbenemid.
Probenecid + Colchicine Patient Counseling
See Literature
