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Probenecid Generic Name & Formulations
Legal Class
Rx
General Description
Probenecid 500mg; scored tabs.
Pharmacological Class
Uricosuric.
How Supplied
Contact supplier.
Manufacturer
Probenecid Indications
Indications
Hyperuricemia associated with gout and gouty arthritis.
Probenecid Dosage and Administration
Adult
250mg twice daily for 1 week, then 500mg twice daily thereafter. Renal impairment, dose adjustments: see literature.
Children
Not recommended.
Probenecid Contraindications
Contraindications
Acute gouty attack. Blood dyscrasias. Uric acid kidney stones. Children <2 yrs of age. Concomitant salicylates (antagonizes uricosuric effect).
Probenecid Boxed Warnings
Not Applicable
Probenecid Warnings/Precautions
Warnings/Precautions
History of peptic ulcer. Renal insufficiency. G6PD deficiency. Maintain adequate hydration. Alkalization of urine may be required. Pregnancy.
Probenecid Pharmacokinetics
See Literature
Probenecid Interactions
Interactions
Affects renal clearance of many drugs (esp. penicillins). Potentiates methotrexate (monitor and reduce methotrexate dose). May potentiate thiopental, ketamine, NSAIDs, oral sulfonylureas, acetaminophen, lorazepam, rifampin, other sulfonamides. Pyrazinamide antagonizes uricosuric effect. May cause falsely high readings of theophylline levels.
Probenecid Adverse Reactions
Adverse Reactions
Headache, dizziness, GI upset, urinary frequency, sore gums, uric acid kidney stones, dermatitis, fever, hematuria, renal colic, blood dyscrasias, hemolytic anemia; rare: severe allergic reactions, anaphylaxis.
Probenecid Clinical Trials
See Literature
Probenecid Note
Notes
Formerly known under the brand name Benemid.
Probenecid Patient Counseling
See Literature
