Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Nalfon Generic Name & Formulations
Legal Class
Rx
General Description
Fenoprofen calcium 200mg, 400mg; caps.
Pharmacological Class
NSAID (arylacetic acid deriv.).
How Supplied
Caps 200mg—100; 400mg—90, 500
Manufacturer
Nalfon Indications
Indications
Rheumatoid arthritis. Osteoarthritis.
Nalfon Dosage and Administration
Adult
Use lowest effective dose for shortest duration. 400mg–600mg 3 or 4 times daily. Max: 3.2g/day.
Children
<18yrs: not established.
Nalfon Contraindications
Contraindications
Aspirin allergy. Coronary artery bypass graft surgery.
Nalfon Boxed Warnings
Boxed Warning
Risk of serious cardiovascular and gastrointestinal events.
Nalfon Warnings/Precautions
Warnings/Precautions
Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Dehydration. Hypovolemia. Advanced renal disease: not recommended. Hyperkalemia. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, renal, and ocular function in long-term therapy. Pre-existing asthma. May mask signs of infection or fever. Discontinue at 1st sign of rash or any other hypersensitivity. Hearing impaired. Elderly. Debilitated. Labor & delivery. Pregnancy (3rd trimester; avoid). Nursing mothers.
Nalfon Pharmacokinetics
See Literature
Nalfon Interactions
Interactions
Avoid concomitant aspirin, salicylates (eg, diflunisal, salsalate) or other NSAIDs. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors (eg, captopril), ARBs (eg, losartan), or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. May be antagonized by phenobarbital. May potentiate protein-bound drugs (eg, hydantoins, sulfonamides, sulfonylureas).
Nalfon Adverse Reactions
Adverse Reactions
Dyspepsia, headache, somnolence, nausea, dizziness, constipation, nervousness, asthenia, peripheral edema; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypertension, hypersensitivity reactions, anemia/blood dyscrasias.
Nalfon Clinical Trials
See Literature
Nalfon Note
Not Applicable
Nalfon Patient Counseling
See Literature
Nalfon Generic Name & Formulations
Legal Class
Rx
General Description
Fenoprofen calcium 200mg, 400mg; caps.
Pharmacological Class
NSAID (arylacetic acid deriv.).
How Supplied
Caps 200mg—100; 400mg—90, 500
Manufacturer
Nalfon Indications
Indications
Mild to moderate pain.
Nalfon Dosage and Administration
Adult
Use lowest effective dose for shortest duration. 200mg every 4–6hrs as needed.
Children
<18yrs: not established.
Nalfon Contraindications
Contraindications
Aspirin allergy. Coronary artery bypass graft surgery.
Nalfon Boxed Warnings
Boxed Warning
Risk of serious cardiovascular and gastrointestinal events.
Nalfon Warnings/Precautions
Warnings/Precautions
Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Dehydration. Hypovolemia. Advanced renal disease: not recommended. Hyperkalemia. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, renal, and ocular function in long-term therapy. Pre-existing asthma. May mask signs of infection or fever. Discontinue at 1st sign of rash or any other hypersensitivity. Hearing impaired. Elderly. Debilitated. Labor & delivery. Pregnancy (3rd trimester; avoid). Nursing mothers.
Nalfon Pharmacokinetics
See Literature
Nalfon Interactions
Interactions
Avoid concomitant aspirin, salicylates (eg, diflunisal, salsalate) or other NSAIDs. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors (eg, captopril), ARBs (eg, losartan), or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. May be antagonized by phenobarbital. May potentiate protein-bound drugs (eg, hydantoins, sulfonamides, sulfonylureas).
Nalfon Adverse Reactions
Adverse Reactions
Dyspepsia, headache, somnolence, nausea, dizziness, constipation, nervousness, asthenia, peripheral edema; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypertension, hypersensitivity reactions, anemia/blood dyscrasias.
Nalfon Clinical Trials
See Literature
Nalfon Note
Not Applicable
Nalfon Patient Counseling
See Literature
