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Keveyis Generic Name & Formulations
Legal Class
Rx
General Description
Dichlorphenamide 50mg; scored tabs.
Pharmacological Class
Carbonic anhydrase inhibitor.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Mechanism of Action
Dichlorphenamide is a carbonic anhydrase inhibitor. However, the precise mechanism by which dichlorphenamide exerts its therapeutic effects in patients with primary periodic paralysis is unknown.
Keveyis Indications
Indications
Primary hyperkalemic or hypokalemic periodic paralysis and related variants.
Keveyis Dosage and Administration
Adult
Initially 50mg twice daily. Adjust dose based on response, at weekly intervals (or sooner if adverse reactions occur); max 200mg daily. Evaluate after 2 months.
Children
Not established.
Keveyis Contraindications
Contraindications
Concomitant high-dose aspirin. Severe pulmonary disease. Hepatic insufficiency. Sulfonamides.
Keveyis Boxed Warnings
Not Applicable
Keveyis Warnings/Precautions
Warnings/Precautions
Discontinue at first sign of skin rash or immune-mediated or idiosyncratic adverse reaction. Adrenocortical insufficiency, hyperchloremic metabolic acidosis, respiratory acidosis: increased risk of hypokalemia. Metabolic acidosis. Monitor serum potassium and bicarbonate at baseline and periodically during treatment; reduce dose or discontinue if hypokalemia or metabolic acidosis develops. Increased risk of falls (esp. elderly, higher doses); consider dose reduction or discontinuation if occurs. Elderly. Pregnancy (Cat.C). Nursing mothers.
Keveyis Pharmacokinetics
Elimination
Half-life: 32-66 hours.
Keveyis Interactions
Interactions
Caution with concomitant low-dose aspirin. Increased risk of hypokalemia with loop or thiazide diuretics, laxatives, antifungals, penicillin, and theophylline.
Keveyis Adverse Reactions
Adverse Reactions
Paresthesia, cognitive disorder, dysgeusia, confusion, hypoesthesia, lethargy, dizziness, nausea, fatigue, muscle spasms, rash; hypersensitivity reactions.
Keveyis Clinical Trials
See Literature
Keveyis Note
Not Applicable
Keveyis Patient Counseling
See Literature
