Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Ibandronate Injection Generic Name & Formulations
Legal Class
Rx
General Description
Ibandronate (as sodium) 3mg/3mL; soln for IV inj.
Pharmacological Class
Bisphosphonate.
See Also
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
Ibandronate inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.
Ibandronate Injection Indications
Indications
Prevention and treatment of postmenopausal osteoporosis.
Limitations of Use
Optimal duration of use has not been determined. For patients at low-risk for fracture: consider drug discontinuation after 3–5yrs.
Ibandronate Injection Dosage and Administration
Adult
Must be given by healthcare professional. Give as IV bolus inj over 15–30secs. 3mg every 3 months; if dose is missed, give as soon as possible, then every 3 months from the date of last inj.
Children
Not established.
Ibandronate Injection Contraindications
Contraindications
Hypocalcemia. Tabs: Esophagus abnormalities which delay esophageal emptying (eg, stricture, achalasia). Inability to stand or sit upright for at least 60mins.
Ibandronate Injection Boxed Warnings
Not Applicable
Ibandronate Injection Warnings/Precautions
Warnings/Precautions
Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Severe renal impairment (CrCl <30mL/min): not recommended. Correct preexisting hypocalcemia, other mineral or bone disturbances before starting. Risk of osteonecrosis of the jaw; consider discontinuing therapy during invasive dental procedures (eg, tooth extraction, implants, surgery). History of bisphosphonate exposure: evaluate for atypical fractures if thigh/groin pain develops; consider withholding therapy until risk/benefit assessment. Ensure adequate Vit. D and calcium intake. Reevaluate periodically. Inj: check renal function before each dose. Pregnancy. Nursing mothers.
Ibandronate Injection Pharmacokinetics
See Literature
Ibandronate Injection Interactions
Interactions
Calcium, aluminum, magnesium, other multivalent cations reduce absorption (separate dosing by at least 60mins). Caution with aspirin, NSAIDs, other GI irritants. May interfere with bone-imaging agents. Inj: concomitant nephrotoxic agents; monitor for renal toxicity.
Ibandronate Injection Adverse Reactions
Adverse Reactions
Back pain, dyspepsia, pain in extremity, diarrhea, headache, myalgia; musculoskeletal pain (discontinue if severe), esophagitis, esophageal or gastric ulcer, jaw osteonecrosis, atypical femur fractures. Inj: inj site reactions, flu-like syndrome, anaphylaxis.
Ibandronate Injection Clinical Trials
See Literature
Ibandronate Injection Note
Notes
Formerly known under the brand name Boniva.
Ibandronate Injection Patient Counseling
See Literature
