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Gelsyn-3 Generic Name & Formulations
Legal Class
Rx
General Description
Sodium hyaluronate 0.84%; per 2mL; soln for intra-articular inj.
Pharmacological Class
Hyaluronan.
How Supplied
Single-use pre-filled syringe—1 (w. needle)
Manufacturer
Generic Availability
NO
Gelsyn-3 Indications
Indications
Treatment of pain in osteoarthritis of the knee in patients who have failed nonpharmacologic therapy and simple analgesics (eg, acetaminophen).
Gelsyn-3 Dosage and Administration
Adult
Remove synovial fluid or effusion before inj. Give as a single intra-articular inj. >21yrs: 2mL in one knee only at weekly intervals for 3 weeks.
Children
≤21yrs: not established.
Gelsyn-3 Contraindications
Contraindications
Knee joint infections. Skin diseases or infections in area of the inj site.
Gelsyn-3 Boxed Warnings
Not Applicable
Gelsyn-3 Warnings/Precautions
Warnings/Precautions
Do not inject by intravascular route. Severe intra-articular effusion. Lymphatic or venous stasis in leg. Advise patients to avoid strenuous or prolonged weight-bearing activities for approx. 48hrs following inj. Pregnancy, nursing mothers: not established.
Gelsyn-3 Pharmacokinetics
See Literature
Gelsyn-3 Interactions
Interactions
Avoid use of disinfectants containing quaternary ammonium salts; hyaluronan can precipitate in their presence. Concomitant other intra-articular inj: not studied.
Gelsyn-3 Adverse Reactions
Adverse Reactions
Inj site pain, arthralgia, joint effusion/warmth/stiffness/swelling, arthritis, gait disturbance, arthropathy.
Gelsyn-3 Clinical Trials
See Literature
Gelsyn-3 Note
Not Applicable
Gelsyn-3 Patient Counseling
See Literature
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