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Etodolac Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Etodolac 400mg, 500mg.
Pharmacological Class
NSAID (pyranocarboxylic acid deriv.).
How Supplied
Contact supplier
Manufacturer
Etodolac Tablets Indications
Indications
Osteoarthritis. Rheumatoid arthritis.
Etodolac Tablets Dosage and Administration
Adult
Use lowest effective dose for shortest duration. Initially 300mg 2–3 times daily, or 400mg twice daily, or 500mg twice daily; usual max 1000mg/day in divided doses. May give 600mg once daily for long-term use.
Children
<18yrs: not established.
Etodolac Tablets Contraindications
Contraindications
Aspirin allergy. Coronary artery bypass graft surgery.
Etodolac Tablets Boxed Warnings
Not Applicable
Etodolac Tablets Warnings/Precautions
Warnings/Precautions
Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Advanced renal disease: not recommended. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic and renal function in long-term therapy. Pre-existing asthma. Discontinue at 1st sign of rash or any other hypersensitivity. Renal or hepatic impairment. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C; 3rd trimester: avoid). Nursing mothers: not recommended.
Etodolac Tablets Pharmacokinetics
See Literature
Etodolac Tablets Interactions
Interactions
Avoid concomitant aspirin, salicylates, phenylbutazone, or other NSAIDs. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. May cause false (+) urinary bilirubin test.
Etodolac Tablets Adverse Reactions
Adverse Reactions
GI upset, dizziness, headache, rash (may be severe), anemia, edema, pruritus, tinnitus; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypersensitivity reactions.
Etodolac Tablets Clinical Trials
See Literature
Etodolac Tablets Note
Notes
Formerly known under the brand names Lodine (caps, tabs); Lodine XL (ext-rel tabs).
Etodolac Tablets Patient Counseling
See Literature
Etodolac Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Etodolac 400mg, 500mg.
Pharmacological Class
NSAID (pyranocarboxylic acid deriv.).
See Also
How Supplied
Contact supplier
Manufacturer
Etodolac Tablets Indications
Indications
Acute pain.
Etodolac Tablets Dosage and Administration
Adult
Use lowest effective dose for shortest duration. Initially 200mg–400mg every 6–8hrs; usual max 1000mg/day in divided doses.
Children
<18yrs: not established.
Etodolac Tablets Contraindications
Contraindications
Aspirin allergy. Coronary artery bypass graft surgery.
Etodolac Tablets Boxed Warnings
Not Applicable
Etodolac Tablets Warnings/Precautions
Warnings/Precautions
Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Advanced renal disease: not recommended. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic and renal function in long-term therapy. Pre-existing asthma. Discontinue at 1st sign of rash or any other hypersensitivity. Renal or hepatic impairment. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C; 3rd trimester: avoid). Nursing mothers: not recommended.
Etodolac Tablets Pharmacokinetics
See Literature
Etodolac Tablets Interactions
Interactions
Avoid concomitant aspirin, salicylates, phenylbutazone, or other NSAIDs. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. May cause false (+) urinary bilirubin test.
Etodolac Tablets Adverse Reactions
Adverse Reactions
GI upset, dizziness, headache, rash (may be severe), anemia, edema, pruritus, tinnitus; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypersensitivity reactions.
Etodolac Tablets Clinical Trials
See Literature
Etodolac Tablets Note
Notes
Formerly known under the brand name Lodine.
Etodolac Tablets Patient Counseling
See Literature
