Etidronate Disodium

Swallow whole; take with a full glass of water (6–8oz) in upright position; do not lie down afterwards. Give once daily (preferred) or in divided doses at least 2hrs before or after food. Paget's: initially 5–10mg/kg/day; max 6 months (if ineffective, or if rapid bone turnover must be suppressed or to reduce elevated cardiac output: 11–20mg/kg/day; max 3 months). May retreat after 3 etidronate-free months if evidence of active disease process exists. Heterotopic ossification: hip replacement: 20mg/kg/day for 1 month before and 3 months after surgery; spinal cord injury: 20mg/kg/day for 2 weeks, then 10mg/kg/day for 10 weeks.