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Diflunisal Generic Name & Formulations
Legal Class
Rx
General Description
Diflunisal 250mg, 500mg; tabs.
Pharmacological Class
Salicylate.
How Supplied
Contact supplier.
Manufacturer
Diflunisal Indications
Indications
Osteoarthritis. Rheumatoid arthritis.
Diflunisal Dosage and Administration
Adult
250–500mg twice daily; max 1.5g/day.
Children
Not recommended.
Diflunisal Contraindications
Contraindications
Aspirin allergy. Varicella or influenza in teenagers. 3rd trimester pregnancy. Coronary artery bypass graft surgery.
Diflunisal Boxed Warnings
Not Applicable
Diflunisal Warnings/Precautions
Warnings/Precautions
Advanced renal disease: not recommended. Active peptic ulcer or GI bleeding. History of GI disease. Cardiac failure. Hypertension. Impaired renal or hepatic function. Volume depletion. Bleeding disorders. Sepsis. Diabetes. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C in 1st and 2nd trimesters). Nursing mothers: not recommended.
Diflunisal Pharmacokinetics
See Literature
Diflunisal Interactions
Interactions
Avoid methotrexate, indomethacin. Oral anticoagulants potentiated. Increased acetaminophen and hydrochlorothiazide serum levels. Reduced absorption with antacids.
Diflunisal Adverse Reactions
Adverse Reactions
Peptic ulcer, GI bleeding, nausea, dyspepsia, GI pain, diarrhea, rash (discontinue if occurs), headache, dizziness, edema, nephritis. See literature re: risk of cardiovascular disease.
Diflunisal Clinical Trials
See Literature
Diflunisal Note
Notes
Formerly known under the brand name Dolobid.
Diflunisal Patient Counseling
See Literature
Diflunisal Generic Name & Formulations
Legal Class
Rx
General Description
Diflunisal 250mg, 500mg; tabs.
Pharmacological Class
Salicylate.
How Supplied
Contact supplier.
Manufacturer
Diflunisal Indications
Indications
Mild to moderate pain.
Diflunisal Dosage and Administration
Adult
0.5–1g once then 250–500mg every 8–12 hrs.
Children
Not recommended.
Diflunisal Contraindications
Contraindications
Aspirin allergy. Varicella or influenza in teenagers. 3rd trimester pregnancy. Coronary artery bypass graft surgery.
Diflunisal Boxed Warnings
Not Applicable
Diflunisal Warnings/Precautions
Warnings/Precautions
Advanced renal disease: not recommended. Active peptic ulcer or GI bleeding. History of GI disease. Cardiac failure. Hypertension. Impaired renal or hepatic function. Volume depletion. Bleeding disorders. Sepsis. Diabetes. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C in 1st and 2nd trimesters). Nursing mothers: not recommended.
Diflunisal Pharmacokinetics
See Literature
Diflunisal Interactions
Interactions
Avoid methotrexate, indomethacin. Oral anticoagulants potentiated. Increased acetaminophen and hydrochlorothiazide serum levels. Reduced absorption with antacids.
Diflunisal Adverse Reactions
Adverse Reactions
Peptic ulcer, GI bleeding, nausea, dyspepsia, GI pain, diarrhea, rash (discontinue if occurs), headache, dizziness, edema, nephritis. See literature re: risk of cardiovascular disease.
Diflunisal Clinical Trials
See Literature
Diflunisal Note
Notes
Formerly known under the brand name Dolobid.
Diflunisal Patient Counseling
See Literature
