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Daypro Generic Name & Formulations
Legal Class
Rx
General Description
Oxaprozin 600mg; scored caplets.
Pharmacological Class
NSAID (propionic acid deriv.).
How Supplied
Caplets—100, 500
Manufacturer
Generic Availability
YES
Daypro Indications
Indications
Rheumatoid arthritis (RA). Osteoarthritis (OA). Juvenile rheumatoid arthritis (JRA).
Daypro Dosage and Administration
Adult
Use lowest effective dose for shortest duration. RA (≥16yrs) or OA: 1.2g once daily; max 1.8g or 26mg/kg daily, whichever is less, in divided doses. Low body weight, severe renal impairment, or on dialysis: initially 600mg once daily; max 1.2g daily.
Children
Use lowest effective dose for shortest duration. <6yrs: not established. JRA: 6–16yrs (22–31kg): 600mg once daily; (32–54kg): 900mg once daily; (≥55kg): 1.2g once daily.
Daypro Contraindications
Contraindications
Aspirin allergy. Coronary artery bypass graft surgery.
Daypro Boxed Warnings
Boxed Warning
Risk of serious cardiovascular and gastrointestinal events.
Daypro Warnings/Precautions
Warnings/Precautions
Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Dehydration. Hypovolemia. Advanced renal disease: not recommended. Hyperkalemia. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, and renal function in long-term therapy. Pre-existing asthma. May mask signs of infection or fever. Discontinue at 1st sign of rash or any other hypersensitivity. Elderly. Debilitated. Labor & delivery. Pregnancy (avoid during ≥30 weeks gestation): increased risk of premature closure of the fetal ductus arteriosus; (20–30 weeks gestation): may cause fetal renal dysfunction/oligohydramnios; if treatment needed, limit dose and duration of use. Nursing mothers.
Daypro Pharmacokinetics
See Literature
Daypro Interactions
Interactions
Avoid concomitant aspirin, salicylates (eg, diflunisal, salsalate) or other NSAIDs. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. Concomitant glyburide: monitor blood glucose at initiation. May cause false (+) results of benzodiazepine urine screening tests.
Daypro Adverse Reactions
Adverse Reactions
Constipation, diarrhea, dyspepsia, nausea, rash (may be serious), edema, anemia, CNS effects, tinnitus, dysuria; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypersensitivity reactions, serious skin reactions (eg, Stevens-Johnson Syndrome, toxic epidermal necrolysis), Drug Reaction with Eosinophilia and Systemic Symptoms (discontinue if occurs), photosensitivity.
Daypro Clinical Trials
See Literature
Daypro Note
Not Applicable
Daypro Patient Counseling
See Literature
