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Syprine Generic Name & Formulations
Legal Class
Rx
General Description
Trientine HCl 250mg; caps.
Pharmacological Class
Chelating agent.
How Supplied
Caps—100
Manufacturer
Syprine Indications
Indications
Wilsons disease in patients who are intolerant of penicillamine.
Syprine Dosage and Administration
Adult
Swallow whole. Take on an empty stomach. 750–1250mg/day in 2–4 divided doses; max 2000mg/day. Increase dose if clinical response not adequate or free serum copper is persistently >20mcg/dL. Determine maintenance dose at 6–12 month intervals.
Children
<6yrs: not recommended. Swallow whole. Take on an empty stomach. 6–12yrs: 500–750mg/day in 2–4 divided doses; max 1500mg/day. Increase dose if clinical response not adequate or free serum copper is persistently >20mcg/dL. Determine maintenance dose at 6–12 month intervals.
Syprine Contraindications
Not Applicable
Syprine Boxed Warnings
Not Applicable
Syprine Warnings/Precautions
Warnings/Precautions
Not for treatment of biliary cirrhosis. Monitor for iron deficiency anemia (esp. women). Monitor for symptoms of fever or skin eruption; take body temperature nightly during 1st month of treatment. Any site of exposure to capsule contents must be washed with water. Do 24-hour urinary copper analysis periodically (eg, every 6–12 months). Pregnancy (Cat.C). Nursing mothers.
Syprine Pharmacokinetics
See Literature
Syprine Interactions
Interactions
Absorption may be inhibited by mineral supplements; separate dosing of iron by at least 2 hours. Separate dosing of any other drug, food, or milk by at least 1 hour.
Syprine Adverse Reactions
Adverse Reactions
Iron deficiency, systemic lupus erythematosus, dystonia, muscular spasm, myasthenia gravis, contact dermatitis.
Syprine Clinical Trials
See Literature
Syprine Note
Not Applicable
Syprine Patient Counseling
See Literature
