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Revonto Generic Name & Formulations
Legal Class
Rx
General Description
Dantrolene sodium 20mg; per vial; lyophilized pwd for IV inj after reconstitution; contains mannitol.
Pharmacological Class
Muscle relaxant (skeletal).
How Supplied
Vial (65mL)—1
Manufacturer
Revonto Indications
Indications
Management of the fulminant hypermetabolism of skeletal muscle characteristic of malignant hyperthermia (MH). Prevention of malignant hyperthermia in susceptible patients during pre-op or sometimes post-op.
Revonto Dosage and Administration
Adults and Children
Treatment: Give by rapid IV push at a minimum of 1mg/kg, continue until symptoms subside or max cumulative dose of 10mg/kg has been reached; if physiologic and metabolic abnormalities reappear, repeat regimen. Prevention: Start approx. 75 mins prior to anesthesia, give 2.5mg/kg by IV infusion over 1hr; may give additional doses during anesthesia or prolonged surgery.
Revonto Contraindications
Not Applicable
Revonto Boxed Warnings
Not Applicable
Revonto Warnings/Precautions
Warnings/Precautions
Institute supportive measures (eg, discontinue MH-triggering agents, increase oxygen requirements, manage metabolic acidosis, cooling if necessary, monitor urinary output and electrolyte imbalance). Monitor for skeletal muscle weakness, difficulty swallowing and choking. Increased risk of hepatic injury (esp. in females or patients >35yrs of age); monitor hepatic function frequently (eg, SGOT, SGPT). Avoid extravasation. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Revonto Pharmacokinetics
See Literature
Revonto Interactions
Interactions
Avoid MH-triggering agents. Concomitant calcium channel blockers (eg, verapamil): not recommended. Caution with concomitant tranquilizers. May potentiate vecuronium-induced neuromuscular block. Protein binding reduced by warfarin or clofibrate; and increased by tolbutamide.
Revonto Adverse Reactions
Adverse Reactions
Loss of grip strength, weakness in the legs, drowsiness, dizziness, thrombophlebitis, tissue necrosis secondary to extravasation, inj site reactions (eg, pain, erythema, swelling); rare: pulmonary edema, urticaria, erythema.
Revonto Clinical Trials
See Literature
Revonto Note
Not Applicable
Revonto Patient Counseling
See Literature
