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Panhematin Generic Name & Formulations
Legal Class
Rx
General Description
Hemin 350mg; per vial; pwd for IV infusion (7mg of hematin/mL after reconstitution); contains sodium carbonate 240mg, sorbitol 335mg; preservative-free.
Pharmacological Class
Delta-aminolevulinic acid synthetase inhibitor.
How Supplied
Single-dose vial—1
Manufacturer
Panhematin Indications
Indications
Amelioration of recurrent attacks of acute intermittent porphyria temporally related to the menstrual cycle in susceptible women, after initial carbohydrate therapy is known or suspected to be inadequate.
Limitations of Use
Intended to prevent an attack from reaching the critical stage of neuronal degeneration. Not effective in repairing neuronal damage.
Panhematin Dosage and Administration
Adult
Consider carbohydrate loading (eg, 400g glucose/day for 1–2 days) before initiation. If improvement unsatisfactory, give 1–4mg/kg/day of hematin via IV infusion over at least 30mins for 3–14 days. In more severe cases, this dose may be repeated no earlier than every 12hrs. Max 6mg/kg of hematin per 24hrs.
Children
<16yrs: not established.
Panhematin Contraindications
Not Applicable
Panhematin Boxed Warnings
Not Applicable
Panhematin Warnings/Precautions
Warnings/Precautions
Administer into large arm vein or a central venous catheter to avoid phlebitis. Contains human plasma; monitor for possible infection transmission (eg, viruses, Creutzfeldt-Jacob disease agent). Monitor iron and serum ferritin in multiple administrations. Latex allergy. Pregnancy (avoid in severe pre-eclampsia). Nursing mothers.
Panhematin Pharmacokinetics
See Literature
Panhematin Interactions
Interactions
Avoid CYP-inducing drugs that increase the activity of δ-aminolevulinic acid synthetase (eg, estrogens, barbituric acid derivatives, steroid metabolites). Avoid concomitant anticoagulants.
Panhematin Adverse Reactions
Adverse Reactions
Headache, pyrexia, infusion site reactions, phlebitis.
Panhematin Clinical Trials
See Literature
Panhematin Note
Not Applicable
Panhematin Patient Counseling
See Literature
