Nexviazyme

Have appropriate medical support and resuscitative equipment readily available. Discontinue immediately and treat appropriately if severe hypersensitivity reaction (eg, anaphylaxis) or severe infusion-associated reactions (IARs) occurs; may rechallenge using slower infusion rates. Withhold temporarily or slow the infusion rate if mild or moderate hypersensitivity reactions or moderate IARs occur. Increased risk for IARs in patients with an acute underlying illness or severe complications from IARs in those with advanced Pompe disease. Fluid volume overload, acute underlying respiratory illness, or compromised cardiac/respiratory function (with fluid restriction): risk for acute cardiorespiratory failure; monitor vitals frequently. Pregnancy. Nursing mothers.