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Kuvan Powder Generic Name & Formulations
Legal Class
Rx
General Description
Sapropterin dihydrochloride 100mg, 500mg; per pkt; pwd for oral soln.
Pharmacological Class
Phenylalanine hydroxylase activator.
See Also
How Supplied
Tabs—120; Packets—1, 30
Manufacturer
Generic Availability
YES
Kuvan Powder Indications
Indications
In conjunction with a phenylalanine (Phe)-restricted diet: to reduce blood Phe levels in hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive phenylketonuria (PKU).
Kuvan Powder Dosage and Administration
Adults and Children
<1 month: not established. Take with food at same time each day. Tabs: swallow whole or may dissolve in 120–240mL water or apple juice (may crush tab) and drink within 15mins (tab may not completely dissolve). Powder: dissolve in 120–240mL water or apple juice (5mL if child weighs ≤10kg) and drink within 30mins. 1 month–6yrs: initially 10mg/kg once daily; if inadequate response may increase to 20mg/kg once daily; if inadequate response after 1 month, discontinue. ≥7yrs: initially 10–20mg/kg once daily; if inadequate response after 1 month, discontinue. Usual range 5–20mg/kg per day; adjust based on blood Phe levels.
Kuvan Powder Contraindications
Not Applicable
Kuvan Powder Boxed Warnings
Not Applicable
Kuvan Powder Warnings/Precautions
Warnings/Precautions
Monitor blood Phe levels after 1 week to assess effect, then periodically. Maintain Phe-restricted diet. Monitor for upper GI mucosal inflammation, hyperactivity. Discontinue if anaphylaxis occurs. Pregnancy. Nursing mothers.
Kuvan Powder Pharmacokinetics
Elimination
Half-life: 6.7 hours (range: 3.9–17 hours).
Kuvan Powder Interactions
Interactions
Monitor neurologic status with concomitant levodopa. Caution with drugs that can inhibit folate metabolism (eg, methotrexate, valproic acid, phenobarbital, trimethoprim). Concomitant drugs that affect nitric oxide-mediated vasorelaxation (eg, PDE-5 inhibitors); monitor BP.
Kuvan Powder Adverse Reactions
Adverse Reactions
Headache, rhinorrhea, pharyngolaryngeal pain, diarrhea, vomiting, cough, nasal congestion; hypersensitivity reactions, gastritis (monitor), hypophenylalaninemia.
Kuvan Powder Clinical Trials
See Literature
Kuvan Powder Note
Not Applicable
Kuvan Powder Patient Counseling
See Literature
