Kanuma

<1 month: not established. Give as IV infusion over ≥2hrs; consider further prolonging infusion time for doses >1mg/kg or if hypersensitivity reactions occur. May consider a 1hr infusion for the 1mg/kg dose in those who tolerate the infusion. ≥1 month: 1mg/kg once every other week; increase to 3mg/kg once every other week if suboptimal response. Infants with rapidly progressive deficiency within first 6 months of life: initially 1mg/kg once weekly; increase to 3mg/kg once weekly if suboptimal response; may further increase to 5mg/kg once weekly if continued suboptimal response. May pre-treat with antipyretics and/or antihistamines.