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Fabrazyme Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Fabrazyme Indications
Indications
Fabrazyme Dosage and Administration
Adults and Children
<2yrs: not established. Pretreat with antihistamines, antipyretics, and/or corticosteroids. Give by IV infusion. ≥2yrs: 1mg/kg every 2 weeks. Initially infuse at a rate of 0.25mg/min; if tolerated, may increase by increments of 0.05–0.08mg/min with each subsequent infusion. <30kg: max rate 0.25mg/min. ≥30kg: minimum duration is 1.5hrs. Slow rate if infusion reactions occur. Rechallenge: initially give a low dose and infusion rate (eg, 0.5mg/kg at 0.01mg/min); once tolerated, may increase dose to 1mg/kg, titrate rate slowly upwards (doubled every 30mins up to max 0.25mg/min); see full labeling.
Fabrazyme Contraindications
Not Applicable
Fabrazyme Boxed Warnings
Not Applicable
Fabrazyme Warnings/Precautions
Warnings/Precautions
Have appropriate medical support measures readily available; discontinue immediately if anaphylaxis or severe hypersensitivity reactions occur. Consider testing for IgE antibodies in patients who experienced suspected hypersensitivity reactions; if positive, may be rechallenged. Risk of infusion-associated reactions; if mild or moderate reaction occurs, temporarily withhold, slow the infusion rate, and/or reduce dose; if severe reactions occur, discontinue immediately. Compromised cardiac function; monitor closely. Pregnancy. Nursing mothers.
Fabrazyme Pharmacokinetics
See Literature
Fabrazyme Interactions
Not Applicable
Fabrazyme Adverse Reactions
Adverse Reactions
Fabrazyme Clinical Trials
See Literature
Fabrazyme Note
Notes
Fabrazyme Patient Counseling
See Literature
