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Cerezyme Generic Name & Formulations
Legal Class
Rx
General Description
Imiglucerase 200 Units, 400 Units; per vial; pwd; for IV infusion after reconstitution.
Pharmacological Class
Beta-glucocerebrosidase analogue.
How Supplied
Vial—1
Manufacturer
Cerezyme Indications
Indications
For long-term enzyme replacement therapy in patients with confirmed Type 1 Gaucher disease that results in one or more of the following conditions: 1) anemia; 2) thrombocytopenia; 3) bone disease; 4) hepatomegaly or splenomegaly.
Cerezyme Dosage and Administration
Adults and Children
<2yrs: not recommended. ≥2yrs: Give by IV infusion over 1–2 hours. Individualize. Initial dose range: 2.5 Units/kg 3 times a week to 60 Units/kg once every 2 weeks.
Cerezyme Contraindications
Not Applicable
Cerezyme Boxed Warnings
Not Applicable
Cerezyme Warnings/Precautions
Warnings/Precautions
Monitor periodically for IgG antibody formation during the first year. Patients previously treated with Ceredase (alglucerase inj) who have developed antibody or hypersensitivity to Ceredase. Monitor for pulmonary hypertension, pneumonia. Pregnancy (Cat.C). Nursing mothers.
Cerezyme Pharmacokinetics
See Literature
Cerezyme Interactions
Not Applicable
Cerezyme Adverse Reactions
Adverse Reactions
GI upset, abdominal pain, rash, pruritus, fatigue, headache, fever, dizziness, chills, backache, tachycardia, inj site reactions, hypersensitivity. Also children: dyspnea, flushing, coughing,
Cerezyme Clinical Trials
See Literature
Cerezyme Note
Not Applicable
Cerezyme Patient Counseling
See Literature
