Carbaglu

Do not swallow whole or crush tabs. Dissolve each tab with at least 2.5mL of water; stir and mix. Swallow mixture orally or via an oral syringe immediately before meals; may administer via NG tube or G-tube. NAGS deficiency (acute hyperammonemia): 100–250mg/kg/day; divided into 2–4 doses rounded to the nearest 100mg; administer with other ammonia lowering therapies (eg, alternate pathway meds, hemodialysis, protein restriction); (chronic hyperammonemia): 10–100mg/kg/day; divided into 2–4 doses rounded to the nearest 100mg; may need other ammonia lowering therapies and protein restriction based on plasma ammonia levels. PA or MMA (acute hyperammonemia): (≤15kg): 150mg/kg/day; (>15kg): 3.3g/m²/day; divided into 2 equal doses (given 12hrs apart) rounded up to the next multiple of 50mg; continue until ammonia level <50micromol/L and max duration of 7 days; administer with other ammonia lowering therapies (eg, IV glucose, insulin, L-carnitine, protein restriction, dialysis). Moderate or severe renal impairment: adjust dosage; see full labeling.