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Zithromax Packets Generic Name & Formulations
Legal Class
Rx
General Description
Azithromycin (as dihydrate) 1g/packet (single dose); banana-cherry flavor.
Pharmacological Class
Macrolide (azalide).
How Supplied
Tabs—30; Z-Pak (6 x 250mg tabs)—3; Tri-Pak (3 x 500mg tabs)—3; Susp 100mg/5mL—15mL; 200mg/5mL—15mL, 22.5mL, 30mL; Single Dose Packets—3, 10; Inj—10
Manufacturer
Generic Availability
NO
Zithromax Packets Indications
Indications
Mild to moderate susceptible infections including acute bacterial exacerbations of COPD, acute bacterial sinusitis, acute otitis media, community-acquired pneumonia, pharyngitis/tonsillitis, uncomplicated skin and skin structure, urethritis, cervicitis, chancroid in men. Treatment and prophylaxis of Mycobacterium avium complex (MAC) infection.
Zithromax Packets Dosage and Administration
Adult
Use packets only for doses equal to 1g. COPD: 500mg once daily for 3 days; or 500mg once for 1 day, then 250mg once daily for 4 days. Sinusitis: 500mg once daily for 3 days. Community-acquired pneumonia, pharyngitis/tonsillitis, skin and skin structure: 500mg once for 1 day, then 250mg once daily for 4 days. Nongonococcal urethritis, cervicitis, chancroid: 1g as a single dose. Urethritis, cervicitis due to N. gonorrhoeae: 2g as a single dose. MAC prevention (alone or combined with rifabutin): 1200mg once weekly. MAC treatment (combined with ethambutol): 600mg once daily.
Children
Use oral susp (not packets). Otitis media: <6mos: not established; ≥6mos: 30mg/kg as a single dose (max 1.5g); or 10mg/kg (max 500mg) once daily for 3 days; or 10mg/kg (max 500mg) once then 5mg/kg (max 250mg) per day for 4 days. Sinusitis: <6mos: not established; ≥6mos: 10mg/kg (max 500mg) once daily for 3 days. Community-acquired pneumonia: <6mos: not established; ≥6mos: 10mg/kg (max 500mg) once for 1 day, then 5mg/kg (max 250mg) once daily for 4 days. Pharyngitis/tonsillitis: <2yrs: not established; ≥2yrs: 12mg/kg (max 500mg) once daily for 5 days.
Zithromax Packets Contraindications
Contraindications
Ketolide allergy. History of cholestatic jaundice/hepatic dysfunction associated with prior use.
Zithromax Packets Boxed Warnings
Not Applicable
Zithromax Packets Warnings/Precautions
Warnings/Precautions
Pneumonia: oral treatment is for mild, community-acquired cases suitable for outpatient therapy only. Discontinue if signs/symptoms of hepatitis occur. Known QT prolongation, proarrhythmic conditions, clinically significant bradycardia: avoid. Potential risk of cardiovascular death. Allergic symptoms may recur after initial successful symptomatic treatment. Myasthenia gravis. Hepatic or renal impairment. Elderly. Pregnancy. Nursing mothers: monitor infants.
Zithromax Packets Pharmacokinetics
See Literature
Zithromax Packets Interactions
Interactions
Avoid concomitant aluminum- or magnesium-containing antacids. Monitor with digoxin, colchicine, phenytoin, warfarin. Monitor for azithromycin toxicity (eg, liver dysfunction, ototoxicity) with nelfinavir. Concomitant Class 1A (eg, quinidine, procainamide), or Class III (eg, dofetilide, amiodarone, sotalol) antiarrhythmics, or others known to prolong the QT interval: avoid.
Zithromax Packets Adverse Reactions
Adverse Reactions
Diarrhea, nausea, abdominal pain, vomiting, rash; hepatotoxicity, torsade de pointes (esp. elderly), C. difficile associated diarrhea; rare: allergic reactions (eg, angioedema, AGEP, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS), lab abnormalities.
Zithromax Packets Clinical Trials
See Literature
Zithromax Packets Note
Not Applicable
Zithromax Packets Patient Counseling
See Literature
