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Zerbaxa Generic Name & Formulations
Legal Class
Rx
General Description
Ceftolozane, tazobactam; 1.5g/vial; pwd for IV infusion after reconstitution; preservative-free; contains sodium chloride 487mg/vial.
Pharmacological Class
Cephalosporin + beta-lactamase inhibitor.
How Supplied
Single-use vials—10
Manufacturer
Generic Availability
NO
Zerbaxa Indications
Indications
Susceptible complicated intra-abdominal infections (cIAI) in combination with metronidazole, complicated urinary tract infections (cUTI), including pyelonephritis, hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).
Zerbaxa Dosage and Administration
Adult
Give by IV infusion over 1hr. ≥18yrs (CrCl >50mL/min): cIAI: 1.5g every 8hrs for 4–14 days (with IV metronidazole 500mg every 8hrs); cUTI: 1.5g every 8hrs for 7 days; HABP/VABP: 3g every 8hrs for 8–14 days. Renal impairment: cIAI, cUTI (CrCl 30–50mL/min): 750mg every 8hrs; (CrCl 15–29mL/min): 375mg every 8hrs; ESRD on hemodialysis: 750mg loading dose, followed by 150mg maintenance dose every 8hrs for remainder of treatment (give on dialysis days). HABP/VABP (CrCl 30–50mL/min): 1.5g every 8hrs; (CrCl 15–29mL/min): 750mg every 8hrs; ESRD on hemodialysis: 2.25g loading dose, followed by 450mg maintenance dose every 8hrs for remainder of treatment (give on dialysis days).
Children
<18yrs: not established (HABP/VABP). Give by IV infusion over 1hr. Birth–<18yrs (eGFR >50mL/min/1.73m2): cIAI: 30mg/kg every 8hrs for 5–14 days (with metronidazole); cUTI: 30mg/kg every 8hrs for 7–14 days. For patients >50kg: do not exceed a max dose of 1.5g. Renal impairment (eGFR ≤50mL/min/1.73m2): not recommended.
Zerbaxa Contraindications
Contraindications
Cephalosporin, penicillin, or other beta-lactam allergy.
Zerbaxa Boxed Warnings
Not Applicable
Zerbaxa Warnings/Precautions
Warnings/Precautions
Discontinue if serious hypersensitivity reactions occur. Monitor CrCl at least daily in those with changing renal function and adjust dose. Renal impairment. Elderly. Pregnancy. Nursing mothers.
Zerbaxa Pharmacokinetics
See Literature
Zerbaxa Interactions
Not Applicable
Zerbaxa Adverse Reactions
Adverse Reactions
Nausea, diarrhea, headache, pyrexia, increased transaminases, renal impairment/failure; C. difficile-associated diarrhea, anaphylaxis; children: also thrombocytosis, leukopenia, abdominal pain, vomiting, anemia.
Zerbaxa Clinical Trials
See Literature
Zerbaxa Note
Not Applicable
Zerbaxa Patient Counseling
See Literature
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