Vowst

— THERAPEUTIC CATEGORIES —
  • Bacterial infections

Vowst Generic Name & Formulations

General Description

Fecal microbiota spores, live-brpk; caps.

How Supplied

Caps—12

Manufacturer

Generic Availability

NO

Mechanism of Action

The mechanism of action has not been established. 

Vowst Indications

Indications

Prevention of recurrence of Clostridioides difficile infection (CDI) in adults following antibiotic treatment for recurrent CDI.

Limitations of Use

Not for treatment of CDI.

Vowst Dosage and Administration

Adult

Complete antibacterial treatment for recurrent CDI 2–4 days prior to intiation. Drink 10oz (296mL) magnesium citrate 1 day prior to and ≥8hrs prior to first dose of Vowst; avoid eating or drinking (except for small amount of water) for ≥8hrs prior to first dose. Take on empty stomach prior to first meal of the day. ≥18yrs: 4 caps once daily for 3 consecutive days. 

Children

<18yrs: not established. 

Vowst Contraindications

Not Applicable

Vowst Boxed Warnings

Not Applicable

Vowst Warnings/Precautions

Warnings/Precautions

Manufactured from human fecal matter. Risk of transmissible infectious agents. Potential presence of food allergens. Acute allergic reactions. Pregnancy. Nursing mothers. 

Vowst Pharmacokinetics

See Literature

Vowst Interactions

Interactions

Avoid concomitant antibiotics. 

Vowst Adverse Reactions

Adverse Reactions

Abdominal distension, fatigue, constipation, chills, diarrhea.

Vowst Clinical Trials

See Literature

Vowst Note

Not Applicable

Vowst Patient Counseling

See Literature

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