Vfend

See full labeling. Infuse IV over 1–3hrs; max rate 3mg/kg per hour. Aspergillosis, Scedosporium and Fusarium: initially 6mg/kg IV every 12hrs for 2 doses, then 4mg/kg every 12hrs; continue for at least 7 days. Candidemia, other deep tissue candida infections: initially 6mg/kg IV every 12hrs for 2 doses, then 3–4mg/kg every 12hrs; treat for at least 14 days after symptoms resolve or following last positive culture, whichever is longer. Both: switch to oral form when tolerated; give 1hr before or after meals. Oral forms (<40kg): 100mg every 12hrs; may increase to 150mg every 12hrs if inadequate response; (≥40kg): 200mg every 12hrs; may increase to 300mg every 12hrs if inadequate response. Esophageal candidiasis: oral forms (<40kg): 100mg every 12hrs; (≥40kg): 200mg every 12hrs; treat for a minimum 14 days, and for at least 7 days after symptoms resolve. Concomitant efavirenz: increase voriconazole dose to 400mg every 12hrs and decrease efavirenz dose to 300mg every 24hrs. Concomitant phenytoin: increase voriconazole dose. Hepatic impairment (mild to moderate): reduce maintenance dose by ½; (severe): see full labeling. Renal impairment (CrCl <50mL/min): oral forms preferred. Duration of therapy, and for dose adjustments: see full labeling.