Veklury Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Veklury Indications
Indications
COVID-19 in patients who are: hospitalized, or not hospitalized and have mild to moderate COVID-19 and are at high risk for progression to severe COVID-19, including hospitalization or death.
Veklury Dosage and Administration
Adults and Children
<1.5kg: not established. Give by IV infusion over 30–120mins. Term neonates (gestational age >37 weeks) and infants <28 days of age (≥1.5kg): initially 2.5mg/kg on Day 1, followed by 1.25mg/kg once daily from Day 2. ≥28 days of age (1.5–<3kg): initially 2.5mg/kg on Day 1, followed by 1.25mg/kg once daily from Day 2; (3–<40kg): initially 5mg/kg on Day 1, followed by 2.5mg/kg once daily from Day 2; (≥40kg): Initially 200mg once on Day 1, followed by 100mg once daily from Day 2. Hospitalized patients not requiring invasive mechanical ventilation and/or ECMO: treat for 5 days; if no improvement, may extend for a total duration of up to 10 days. Hospitalized patients requiring invasive mechanical ventilation and/or ECMO: treat for 10 days. Nonhospitalized patients: treat for 3 days. For pediatric pts weighing 1.5–<40kg: use only the lyophilized pwd dosage form.
Veklury Contraindications
Not Applicable
Veklury Boxed Warnings
Not Applicable
Veklury Warnings/Precautions
Warnings/Precautions
Should only be administered in a hospital or in a healthcare setting providing acute care. Obtain LFTs and prothrombin time prior to and during treatment. Consider discontinuing if ALT levels increase to >10×ULN. Discontinue if ALT elevation is accompanied by signs/symptoms of liver inflammation. Monitor for hypersensitivity reactions during and for at least 1hr after infusion; discontinue immediately if significant reactions occur. Elderly (monitor). Pregnancy. Nursing mothers.
Veklury Pharmacokinetics
Absorption
Time to maximum peak concentration: 0.67–0.68 hour.
Distribution
Plasma protein bound: 88–93.6%.
Elimination
Renal (10%). Half-life: 1 hour.
Veklury Interactions
Interactions
Veklury Adverse Reactions
Adverse Reactions
Veklury Clinical Trials
See Literature
Veklury Note
Not Applicable
Veklury Patient Counseling
See Literature
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