Tybost

See Contraindications. Concomitant nephrotoxic agents with cobicistat + TDF: not recommended. Concomitant darunavir 600mg twice daily or darunavir in combination with efavirenz, nevirapine, etravirine; atazanavir in combination with etravirine or efavirenz (in treatment-experienced); more than 1 antiretroviral that requires PK enhancement, other HIV-1 protease inhibitors (eg, fosamprenavir, saquinavir, tipranavir), rivaroxaban, voriconazole, boceprevir, simeprevir, salmeterol, avanafil: not recommended. Concomitant lopinavir/ritonavir, other ritonavir- or cobicistat-containing fixed-dose combination tabs or regimens: not recommended. May need to adjust dose of dasatinib, nilotinib, colchicine, sildenafil, tadalafil, vardenafil, perphenazine, risperidone, thioridazine, buprenorphine, buprenorphine/naloxone, methadone, tramadol, bosentan, rifabutin, and sedatives/hypnotics; see full labeling. May potentiate apixaban (with atazanavir or darunavir); betrixaban, dabigatran, edoxaban (with atazanavir). Concomitant maraviroc: give maraviroc 150mg twice daily. Concomitant quetiapine: consider alternative antiretrovirals; if necessary, reduce quetiapine to ⅙ of current dose and monitor. Monitor with antiarrhythmics, digoxin, clonazepam, SSRIs, TCAs, trazodone, antifungals, fentanyl, immunosuppressants, other statins (eg, atorvastatin, rosuvastatin), β-blockers, calcium channel blockers. Monitor INR with warfarin. Concomitant antibacterials (eg, clarithromycin, erythromycin, telithromycin), CYP3A-inducing anticonvulsants that are not contraindicated (eg, eslicarbazepine, oxcarbazepine), corticosteroids (eg, oral dexamethasone, betamethasone): consider alternatives. Concomitant vincristine, vinblastine: monitor for hematologic or GI adverse effects. Concomitant hormonal contraceptives: consider additional or alternative (non-hormonal) contraception. Separate dosing with concomitant H₂ receptor antagonists, PPIs (not recommended in treatment-experienced), or antacids (at least 2hrs).