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Trimethoprim Generic Name & Formulations
Legal Class
Rx
General Description
Trimethoprim 100mg, 200mg; tabs.
Pharmacological Class
Folic acid inhibitor.
How Supplied
Contact supplier.
Manufacturer
Trimethoprim Indications
Indications
Treatment of initial episodes of uncomplicated UTI due to susceptible strains (E. coli, P. mirabilis, K. pneumoniae, Enterobacter species, coagulase-negative Staphylococcus species, including S. saprophyticus).
Trimethoprim Dosage and Administration
Adult
Treat for 10 days. 100mg every 12 hours or 200mg every 24 hours. CrCl 15–30mL/min: 50mg every 12 hours. CrCl<15mL/min: not recommended.
Children
Not recommended.
Trimethoprim Contraindications
Contraindications
Megaloblastic anemia due to folate deficiency.
Trimethoprim Boxed Warnings
Not Applicable
Trimethoprim Warnings/Precautions
Warnings/Precautions
May interfere with hematopoieses (esp. when given in large doses and/or prolonged periods). Obtain CBCs if signs of serious blood disorder develop, discontinue if significant reduction in any formed blood element is found. Possible folate deficiency. Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers.
Trimethoprim Pharmacokinetics
See Literature
Trimethoprim Interactions
Interactions
May potentiate phenytoin. May interfere with serum methotrexate assay, Jaffe alkaline picrate reaction assay for creatinine.
Trimethoprim Adverse Reactions
Adverse Reactions
Rash, pruritus, GI upset, blood dyscrasias, hyperkalemia, hyponatremia, fever, increased BUN, serum creatinine; rare: aseptic meningitis, cholestatic jaundice, hypersensitivity reactions.
Trimethoprim Clinical Trials
See Literature
Trimethoprim Note
Not Applicable
Trimethoprim Patient Counseling
See Literature
